A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo. [PDF]
V. Wayne Engleman+7 more
openalex +1 more source
Advances in miRNA research: Unraveling the complexities of gene regulation
Overview of miRNA‐mediated regulation in key biological processes. This illustration offers a comprehensive view of the diverse functions that microRNAs perform in governing various biological processes, highlighting their profound significance within the complex web of gene expression and cellular function.
Jiawei Zheng, Guoqing Zhang, Linzhu Ren
wiley +1 more source
Inhibition of Bone Resorption and Anti-Inflammatory Effect of 7-Hydroxycoumarin in an Animal Model of Lipopolysaccharide-Induced Periodontal Disease. [PDF]
Ferreira LTB+5 more
europepmc +1 more source
Nanoparticles Functionalized with Polymer Brushes for Gene Delivery
The engineering of the next generation gene delivery vectors requires the precise control of the architecture and physicochemical interactions controlling the transport, targeting, uptake, and release of nucleic acid materials to targeted cells. Polymer brush‐functionalized nanomaterials offer unprecedented control over such design and properties, and ...
Carlos E. Neri‐Cruz, Julien E. Gautrot
wiley +1 more source
FABP4 inhibition suppresses bone resorption and protects against postmenopausal osteoporosis in ovariectomized mice. [PDF]
Xie Q+11 more
europepmc +1 more source
Inhibition by a new bisphosphonate (AHBuBP) of bone resorption induced by the MBT-2 tumor of mice
Ryosuke Nemoto+3 more
openalex +1 more source
Increased biochemical markers of bone formation and resorption in primary hyperparathyroidism with special reference to patients with mild disease [PDF]
Valdemarsson+3 more
openalex +1 more source
Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang+5 more
wiley +1 more source
Altered microRNA expression correlates with reduced TLR2/4-dependent periodontal inflammation and bone resorption induced by polymicrobial infection. [PDF]
Jeepipalli S+11 more
europepmc +1 more source