Results 71 to 80 of about 1,145,483 (297)

Genistein Prevents Bone Resorption Diseases by Inhibiting Bone Resorption and Stimulating Bone Formation

Biological and Pharmaceutical Bulletin, 2003
Genistein, a soybean-derived isoflavone, has been shown to suppress osteoclastic bone resorption. To clarify the mechanisms underlying this action, we investigated the effects of genistein on the differentiation, cytoskeleton and function in mice osteoclasts in vitro and bone metabolism in ovariectomized rats.Primary OCs were isolated from 3 week-old ...
Li, Binbin, Yu, Shifeng
openaire   +3 more sources

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

Advanced Science, EarlyView.
Mechanical orthodontic treatment for malocclusion is limited by slow remodeling and risks due to poor biomechanical sensing. This study shows that static magnetic fields (SMFs) enhance mechanical sensation in periodontal ligament cells, promoting inflammation and osteoclast activity.
Yiling Lou, Jiwei Sun, Peng Chen, Caihong Mao, Junyuan Zhang, Haoqi Lei, Xiaoqing Han, Yaxuan Zhang, Yuheng Jiang, Yulin Jia, Bin Su, Lili Chen   +11 more
wiley   +1 more source

Capture the fracture - use of bone turnover markers in clinical practice [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2016
Bone is a living tissue, metabolically very active, with the level of turnover of about 10% per year. Bone remodeling is a well-balanced process of bone resorption, induced by osteoclasts and bone formation maintained osteoblasts.
Vuksanović Miljanka, Beljić-Živković Teodora   +1 more
doaj   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

DIAGNOSIS OF THE ALVEOLAR BONE CONDITION IN CASES OF TEETH WITH ANTERIOR CROSS BITE [PDF]

Journal of IMAB
Anterior cross bite is an occlusal etiological factor for the occurrence of gingival recession and resorption of the alveolar bone. Aim: To examine the condition of the alveolar bone in relation to incisor inclination in subjects with anterior cross ...
Stilyana Krasteva, Anzhelina Krasteva, Silviya Krasteva, Nikolay Yanev   +3 more
doaj   +1 more source

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Nature Communications, 2020
Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy ...
Megan M. Weivoda, Chee Kian Chew, David G. Monroe, Joshua N. Farr, Elizabeth J. Atkinson, Jennifer R. Geske, Brittany Eckhardt, Brianne Thicke, Ming Ruan, Amanda J. Tweed, Louise K. McCready, Robert A. Rizza, Aleksey Matveyenko, Moustapha Kassem, Thomas Levin Andersen, Adrian Vella, Matthew T. Drake, Bart L. Clarke, Merry Jo Oursler, Sundeep Khosla   +19 more
doaj   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

RACK1 interaction with c-Src is essential for osteoclast function

Experimental and Molecular Medicine, 2019
Bone disease: scaffolding protein essential for bone resorption The interaction between RACK1, a so-called scaffolding protein that can assemble components of a signaling pathway into complexes, and c-Src, an enzyme involved in the re-organization of the
Jin Hee Park, Eutteum Jeong, Jingjing Lin, Ryeojin Ko, Ji Hee Kim, Sol Yi, Youngjin Choi, In-Cheol Kang, Daekee Lee, Soo Young Lee   +9 more
doaj   +1 more source

CELLULAR BIOLOGY OF BONE RESORPTION

Biological Reviews, 1993
SummaryPast knowledge and the recent developments on the formation, activation and mode of action of osteoclasts, with particular reference to the regulation of each individual step, have been reviewed. The following conclusions of consensus have emerged.1.
MONE ZAIDI, A. S. M. TOWHIDUL ALAM, VIJAI S. SHANKAR, BRIDGET E. BAX, CHRISTOPHER M. R. BAX, BALJIT S. MOONGA, PETER J. R. BEVIS, CLIFFORD STEVENS, DAVID R. BLAKE, MICHAEL PAZIANAS, CHRISTOPHER L. H. HUANG   +10 more
openaire   +3 more sources