Results 51 to 60 of about 156,692 (263)

Clinical and radiographic findings without the use of bone substitute materials in extraction sockets and delayed implant placement- A case series

Journal of Oral Biology and Craniofacial Research, 2020
Aim: To observe clinically and radiographically (CBCT), the extent of bone resorption in extraction socket without the use of bone graft substitutes and delayed implant placement. Material and methods: 50 compliant patients were selected for study.
Lanka Mahesh, Jose Luis Calvo Guirado, Sagrika Shukla, Varun Raj Kumar, Yuvika Raj Kumar   +4 more
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Capture the fracture - use of bone turnover markers in clinical practice [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2016
Bone is a living tissue, metabolically very active, with the level of turnover of about 10% per year. Bone remodeling is a well-balanced process of bone resorption, induced by osteoclasts and bone formation maintained osteoblasts.
Vuksanović Miljanka, Beljić-Živković Teodora   +1 more
doaj   +1 more source

Bone resorption: supporting immunometabolism [PDF]

Biology Letters, 2018
Activation of the immune system is associated with an increase in the breakdown of various peripheral tissues, including bone. Despite the widely appreciated role of inflammatory mediators in promoting bone resorption, the functional value behind this process is not completely understood.
Gustav van Niekerk, Megan Mitchell, Anna-Mart Engelbrecht   +2 more
openaire   +2 more sources

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Orchestrated Engineered Polyphenol‐Peptide Condensates Coupled With β‐GP Reverses Diabetic Osteoporosis by Remodeling Mitophagy

Advanced Science, EarlyView.
A multifunctional β‐GP@EGCG‐E7 nanoplatform is engineered by polyphenol–peptide condensation and phosphate loading. Bone‐targeted delivery, antioxidant and anti‐inflammatory activity, and mitophagy restoration are integrated in one system, enabling protection of osteoblasts and endothelial cells and promoting bone regeneration under diabetic ...
Xiuyun Xu, Meiqin Zhang, Ting Wu, Erfan Wei, Andrei Y. Hancharou, Zeying Wang, Zijuan Wang, Letian Lv, Likun Wu, Xingtong Pan, Qiyue Zhu, Xinyi Dong, Hao Liu, Yongsheng Zhou   +13 more
wiley   +1 more source

Cholesterol and Bone Resorption: Yet Another Link Between the Bone and Cardiovascular Systems

Endocrines
This review examines the relationship between cholesterol and bone resorption. It seeks to elucidate the dependence of bone turnover on cholesterol metabolism by highlighting the common inhibitory effect of both statins and nitrogen-containing ...
Gordon L. Klein
doaj   +1 more source

Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

Nature Communications, 2020
Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy ...
Megan M. Weivoda, Chee Kian Chew, David G. Monroe, Joshua N. Farr, Elizabeth J. Atkinson, Jennifer R. Geske, Brittany Eckhardt, Brianne Thicke, Ming Ruan, Amanda J. Tweed, Louise K. McCready, Robert A. Rizza, Aleksey Matveyenko, Moustapha Kassem, Thomas Levin Andersen, Adrian Vella, Matthew T. Drake, Bart L. Clarke, Merry Jo Oursler, Sundeep Khosla   +19 more
doaj   +1 more source

CELLULAR BIOLOGY OF BONE RESORPTION

Biological Reviews, 1993
SummaryPast knowledge and the recent developments on the formation, activation and mode of action of osteoclasts, with particular reference to the regulation of each individual step, have been reviewed. The following conclusions of consensus have emerged.1.
MONE ZAIDI, A. S. M. TOWHIDUL ALAM, VIJAI S. SHANKAR, BRIDGET E. BAX, CHRISTOPHER M. R. BAX, BALJIT S. MOONGA, PETER J. R. BEVIS, CLIFFORD STEVENS, DAVID R. BLAKE, MICHAEL PAZIANAS, CHRISTOPHER L. H. HUANG   +10 more
openaire   +3 more sources

A Periosteum‐Inspired Janus Piezoelectric Scaffold Using Bioenergetic‐Driven H‐Type Vascularization for Diabetic Bone Regeneration

Advanced Science, EarlyView.
A periosteum‐inspired Janus piezoelectric scaffold converts micromechanical forces into electrical signals and synergizes with controlled resveratrol release. This dual action reprograms endothelial metabolism, drives H‑type vessel formation, and restores bone–vessel coupling in diabetic bone defects.
Kai Wang, Kai Jiang
wiley   +1 more source