Results 31 to 40 of about 1,145,483 (297)

Systemic alendronate prevents resorption of necrotic bone during revascularization. A bone chamber study in rats

BMC Musculoskeletal Disorders, 2002
Background Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of resorption of necrotic bone during revascularization, before new ...
Aspenberg Per, Åstrand Jörgen
doaj   +1 more source

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

eLife, 2021
Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05–099 potently inhibits salt inducible kinases (SIKs) and may represent a ...
Cheng-Chia Tang, Christian D Castro Andrade, Maureen J O'Meara, Sung-Hee Yoon, Tadatoshi Sato, Daniel J Brooks, Mary L Bouxsein, Janaina da Silva Martins, Jinhua Wang, Nathanael S Gray, Barbara Misof, Paul Roschger, Stephane Blouin, Klaus Klaushofer, Annegreet Velduis-Vlug, Yosta Vegting, Clifford J Rosen, Daniel O'Connell, Thomas B Sundberg, Ramnik J Xavier, Peter Ung, Avner Schlessinger, Henry M Kronenberg, Rebecca Berdeaux, Marc Foretz, Marc N Wein   +25 more
doaj   +1 more source

Bone fractures after menopause [PDF]

, 2010
Every year 30% of individuals above age 65 fall, and falls are the principal cause of bone fractures. To reduce fracture incidence requires both prevention of falls and maintenance of bone strength.PubMed searches were performed, for studies of the ...
Ralston, Stuart H., J. L. Evers, Baird, D. T., A. Volpe, Ralston, S.H., Brandi, M.L., G. Benagiano, Brandi, Maria Luisa, S. H. Ralston, P.G. Crosignani, P. Bouchard, Rizzoli, R., ESHRE Capri Workshop Grp, Barlow, David H., La Vecchia, C., Negri, E., M. L. Brandi, P. G. Crosignani, Rizzoli, Rene, Benagiano, G., S. E. Papapoulos, Evers, J.L.H., D. H. Barlow, J. Collins, C. La Vecchia, Baird, D.T., Negri, Eva, Crosignani, P. G., Papapoulos, Socrates E., Glasier, A., R. Rizzoli, Barlow, D.H., A. Glasier, Vecchia, C. la, Collins, J., D. T. Baird, Volpe, A., Bouchard, P., Crosignani, P.G., Bouchard, Philippe, ?, ?, Papapoulos, S.E., E. Negri, Evers, J. L. H., ESHRE Capri Workshop Group., La Vecchia C, Glasier A, Brandi ML, Crosignani PG, Barlow DH, Rizzoli R, Bouchard P, Benagiano G, Volpe A, Evers JLH, Negri E, Ralston SH, Papapoulos SE, Baird DT, Collins J   +59 more
core   +1 more source

Immunoreactive collagenase and bone resorption

Biochimica et Biophysica Acta (BBA) - General Subjects, 1981
1. Active mouse bone collagenase is excluded from its inhibitory antibody by preincubation of that antibody with various forms of inactive enzyme, e.g. 'procollagenase', some collagenase-inhibitor complexes or partially denatured or degraded collagenase. This property allows the detection of several enzymatically inactive forms of collagenase. 2.
Francoisgillet, C., Delaisse, JM., Eeckhout, Yves, Vaes, Gilbert   +3 more
openaire   +3 more sources

Repair of microdamage in osteonal cortical bone adjacent to bone screw.

PLoS ONE, 2014
Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits.
Lei Wang, Tingjun Ye, Lianfu Deng, Jin Shao, Jin Qi, Qi Zhou, Li Wei, Shijing Qiu   +7 more
doaj   +1 more source

Hormone-stimulated modulation of endocytic trafficking in osteoclasts [PDF]

, 2012
Copyright @ 2012 Stenbeck, Lawrence and Albert. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and ...
Stenbeck, G, Anthony P. Albert, Albert, Anthony P., Lawrence, Kevin M., Lawrence, KM, Kevin M. Lawrence, Gudrun eStenbeck, Stenbeck, Gudrun, Anthony P Albert, Gudrun Stenbeck, Albert, AP, Kevin M Lawrence   +11 more
core   +1 more source

Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency

Journal of Pharmacological Sciences, 2011
Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo.
Suguru Harada, Tsukasa Tominari, Chiho Matsumoto, Michiko Hirata, Morichika Takita, Masaki Inada, Chisato Miyaura   +6 more
doaj   +1 more source

ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts

Frontiers in Cell and Developmental Biology, 2021
Bone homeostasis is a metabolic balance between the new bone formation by osteoblasts and old bone resorption by osteoclasts. Excessive osteoclastic bone resorption results in low bone mass, which is the major cause of bone diseases such as rheumatoid ...
Xinyue Liang, Yafei Hou, Lijuan Han, Shuxiang Yu, Yunyun Zhang, Xiumei Cao, Jianshe Yan, Jianshe Yan   +7 more
doaj   +1 more source

The Role of Bone and Root Resorption on the Biomechanical Behavior of Mandibular Anterior Teeth Subjected to Orthodontic Forces: A Finite Element Approach

Biomedicines
Aims: This study was conducted to systematically evaluate the biomechanical impact of varying degrees of root and bone resorption resulting from periodontitis and orthodontic tooth movement (OTM) on the mandibular anterior teeth.
Jana Flatten, Thomasz Gedrange, Christoph Bourauel, Ludger Keilig, Anna Konermann   +4 more
doaj   +1 more source

P38 mitogen-activated protein kinase inhibitor, FR167653, inhibits parathyroid hormone related protein-induced osteoclastogenesis and bone resorption. [PDF]

PLoS ONE, 2011
p38 mitogen-activated protein kinase (MAPK) acts downstream in the signaling pathway that includes receptor activator of NF-κB (RANK), a powerful inducer of osteoclast formation and activation.
Huiren Tao, Mina Okamoto, Masataka Nishikawa, Hideki Yoshikawa, Akira Myoui   +4 more
doaj   +1 more source