Results 31 to 40 of about 251,654 (302)

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]

, 2017
Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran, Blyth, Karen, Charlesworth, Gemma, Daroszewska, Anna, Ford, Catriona, King, Ayala, Leung, Hing Y., Loveridge, Carolyn J., Mui, Ernest J., Prior, Amanda, Rose, Lorraine, Salji, Mark, Sansom, Owen, Tan, Ee Hong, van ’t Hof, Rob J., Welsh, Michelle   +15 more
core   +2 more sources

The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits [PDF]

, 2013
Odanacatib (ODN) is a bone resorption inhibitor which differs from standard antiresorptives by its ability to reduce bone resorption without decreasing bone formation. What is the reason for this difference?
Andersen, Thomas Levin, Delaissé, Jean-Marie, Duong, Le T, Jensen, Pia Rosgaard, Pennypacker, Brenda L   +4 more
core   +1 more source

Repair of microdamage in osteonal cortical bone adjacent to bone screw.

PLoS ONE, 2014
Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits.
Lei Wang, Tingjun Ye, Lianfu Deng, Jin Shao, Jin Qi, Qi Zhou, Li Wei, Shijing Qiu   +7 more
doaj   +1 more source

P38 mitogen-activated protein kinase inhibitor, FR167653, inhibits parathyroid hormone related protein-induced osteoclastogenesis and bone resorption. [PDF]

PLoS ONE, 2011
p38 mitogen-activated protein kinase (MAPK) acts downstream in the signaling pathway that includes receptor activator of NF-κB (RANK), a powerful inducer of osteoclast formation and activation.
Huiren Tao, Mina Okamoto, Masataka Nishikawa, Hideki Yoshikawa, Akira Myoui   +4 more
doaj   +1 more source

Nobiletin, a Polymethoxy Flavonoid, Suppresses Bone Resorption by Inhibiting NFκB-Dependent Prostaglandin E Synthesis in Osteoblasts and Prevents Bone Loss Due to Estrogen Deficiency

Journal of Pharmacological Sciences, 2011
Nobiletin, a polymethoxy flavonoid, prevents cancer and inflammation, but the roles of nobiletin in bone are unclear. We examined the effects of nobiletin on bone resorption in vitro and on bone mass in ovariectomized (OVX) mice in vivo.
Suguru Harada, Tsukasa Tominari, Chiho Matsumoto, Michiko Hirata, Morichika Takita, Masaki Inada, Chisato Miyaura   +6 more
doaj   +1 more source

ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts

Frontiers in Cell and Developmental Biology, 2021
Bone homeostasis is a metabolic balance between the new bone formation by osteoblasts and old bone resorption by osteoclasts. Excessive osteoclastic bone resorption results in low bone mass, which is the major cause of bone diseases such as rheumatoid ...
Xinyue Liang, Yafei Hou, Lijuan Han, Shuxiang Yu, Yunyun Zhang, Xiumei Cao, Jianshe Yan, Jianshe Yan   +7 more
doaj   +1 more source

Bone Resorption by Osteocytes

Experimental Biology and Medicine, 1968
SummaryOsteocyte lacunae were measured in normal rats and in rats in which periosteal hypertrophy had been induced at the adductor longus-pectineus insertion. Lacunae in the cortex beneath the periosteal hypertrophy were significantly larger than lacunae in the cortex of the opposite side of the femur from the hypertrophy.
J. F. Shea, J. J. Taylor, V. L. Yeager, J. J. Taylor   +3 more
openaire   +2 more sources

Effect of carbohydrate feeding on the bone metabolic response to running [PDF]

, 2015
Bone resorption is increased after running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. This study investigated the immediate and short-term bone metabolic responses
Craig Sale, Ian Varley, Jonathan C. Y. Tang, Julie P. Greeves, Peake JM, Ruth M. James, Thomas W. Jones, William D. Fraser, Zweig MH   +8 more
core   +1 more source

Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures [PDF]

, 2014
The basic mechanisms by which strontium ranelate acts on bone are still unclear. We show that an important action of strontium salts is to block calcification in cultures of osteoblasts, the bone-forming cells.
A Barbara, A Caudrillier, AF Donneau, AS Hurtel-Lemaire, C Roux, D. P. Wornham, E Bonnelye, E Canalis, F Yang, FE McCaslin, G Boivin, GJ Atkins, GM Blake, HB Pan, I Schrooten, I Schrooten, I Schrooten, I. R. Orriss, IR Orriss, IR Orriss, IR Orriss, J Christoffersen, JJ Patel, JY Reginster, JY Reginster, M Grynpas, M Yamaguchi, M. O. Hajjawi, MA Karsdal, MS Rybchyn, N Chattopadhyay, N Takahashi, O Bruyere, O Fromigue, P Ammann, P Zioupos, PC D’Haese, PJ Marie, PJ Marie, PJ Marie, PJ Marie, PJ Meunier, SC Verberckmoes, SC Verberckmoes, T. R. Arnett   +44 more
core   +3 more sources

The Role of Bone and Root Resorption on the Biomechanical Behavior of Mandibular Anterior Teeth Subjected to Orthodontic Forces: A Finite Element Approach

Biomedicines
Aims: This study was conducted to systematically evaluate the biomechanical impact of varying degrees of root and bone resorption resulting from periodontitis and orthodontic tooth movement (OTM) on the mandibular anterior teeth.
Jana Flatten, Thomasz Gedrange, Christoph Bourauel, Ludger Keilig, Anna Konermann   +4 more
doaj   +1 more source