Results 81 to 90 of about 64,880 (302)

Bone formation on calcium phosphate bone substitute materials

, 2010
A large number of bone substitute materials are available; for which some authors claim osteoconductivity and some osteoinductivity. In order to rank these materials an in vivo analysis was carried out.
Samizadeh, S.
core  

The Auxiliary Role of Heparin in Bone Regeneration and its Application in Bone Substitute Materials

, 2022
Bone regeneration in large segmental defects depends on the action of osteoblasts and the ingrowth of new blood vessels. Therefore, it is important to promote the release of osteogenic/angiogenic growth factors.
Zhang, Dingmei, Xiao, Lan, Wang, Xin, Ma, Yaping, Wang, Weiqun, Zhang, Yi, Wang, Jing   +6 more
core   +1 more source

Updates on Bone Grafts and Substitutes

Revista Brasileira de Ortopedia
Abstract Bone defects caused by trauma, infections, neoplasms, and other conditions are commonly treated with autologous grafts, which are considered the gold standard due to their osteoinduction, osteoconduction, and osteogenesis properties. However, their use has limitations, including limited availability, donor-site morbidity, and
Edgard Eduard Engel, Nelson Fabrício Gava, Mariana Avelino dos Santos, Leonardo Gomes Baldoino, Lucas Klarosk Ismael, Luis Felipe Miras Modolo   +5 more
openaire   +4 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Preclinical evaluation of a new synthetic carbonate apatite bone substitute on periodontal regeneration in intrabony defects. [PDF]

OBJECTIVE To evaluate the potential of a novel synthetic carbonate apatite bone substitute (CO3 Ap-BS) on periodontal regeneration. BACKGROUND The use of various synthetic bone substitutes as a monotherapy for periodontal regeneration mainly ...
Imber, Larissa Carmela, Stähli, Alexandra, Imber, Jean-Claude, Bosshardt, Dieter Daniel, Muñoz, Fernando, Sculean, Anton, Roccuzzo, Andrea, Weusmann, Jens   +7 more
core   +1 more source

Carbonate apatite as a bone substitute material. A review

, 2023
INTRODUCTION:The reconstruction of bone defects, caused by traumas, tumors, infections, and genetic disorders, is a major problem in orthopedic surgery, maxillofacial and oral surgery, plastic surgery, dental implantology, otorhinolaryngology, etc ...
Yotsova, Ralitsa; Medical University of Varna, Peev, Stefan; Medical University of Varna   +1 more
core   +1 more source

A ceramic bone substitute containing gentamicin gives good outcome in trochanteric hip fractures treated with dynamic hip screw and in revision of total hip arthroplasty: a case series

BMC Musculoskeletal Disorders, 2018
Background The primary objective was to investigate the clinical and radiological outcome in patients undergoing major hip surgery using a novel antibiotic containing bone substitute for local augmentation in trochanteric fracture fixation or revision of
Mindaugas Stravinskas, Sarunas Tarasevicius, Simonas Laukaitis, Malin Nilsson, Deepak Bushan Raina, Lars Lidgren   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect

, 2013
The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Henrich, Dirk, Marzi, Ingo, Seebach, Caroline, Flinspach, Armin Niklas, Wenger, Florian, Warzecha, Jörg   +5 more
core   +1 more source