Results 101 to 110 of about 92,559 (349)

Medicare Reimbursement for Total Joint Arthroplasty: The Driving Forces. [PDF]

, 2016
BACKGROUND: Total joint arthroplasty is a large and growing part of the U.S. Medicare budget, drawing attention to how much providers are paid for their services. The purpose of this study was to examine the variables that affect total joint arthroplasty
Howley, Michael, Padegimas, Eric M., Purtill, James J., Rothman, Richard H., Verma, Kushagra, Zmistowski, Benjamin   +5 more
core   +1 more source

Bone grafts versus synthetic bone substitutes in the treatment of benign bone tumors [PDF]

, 2021
Costache Mihai-Aurel, Iordache Sergiu Andrei, Şerban Bogdan, Spiridonică Dumitru Răzvan, Popa Mihnea Ioan Gabriel, Rascu Angel Ştefan, Adrian Cursaru   +6 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells

, 2011
Modern tissue engineering strategies combine living cells and scaffold materials to develop biological substitutes that can restore tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their ...
Ahn, Jong-Hyun, Andersen, Henrik, Bae, Sukang, Ee, Pui-Lai R., Hong, Byung Hee, Khaw, Clement, Makam, Venkata S., Nayak, Tapas R., Pastorin, Giorgia, Xu, Xiangfan, Özyilmaz, Barbaros   +10 more
core   +1 more source

Effect of pH and temperature on the morphology and phases of co-precipitated hydroxyapatite [PDF]

, 2012
This paper reports a high-yield process to fabricate biomimetic hydroxyapatite nano-particles or nano-plates. Hydroxyapatite is obtained by simultaneous dripping of calcium chloride and ammonium hydrogen phosphate solutions into a reaction vessel ...
AG Evans, B Viswanath, B-H Yoon, C Liu, C. A. Wang, E Gentleman, FA Muller, H-B Zhang, H-W Kim, H. R. Le, IS Neira, J Yana, K. Y. Chen, M Kikuchi, M Kikuchi, M Kikuchi, M Rajkumar, MA Meyers, RZ Wang, S Liao, S Manara, S Yunoki, T Ma, VM Rusu, W Zhang   +24 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Micro-CT Analysis of Bone Healing in Rabbit Calvarial Critical-Sized Defects with Solid Bioactive Glass, Tricalcium Phosphate Granules or Autogenous Bone

eJournal of Oral Maxillofacial Research, 2016
Objectives: The purpose of the present study was to evaluate bone healing in rabbit critical-sized calvarial defects using two different synthetic scaffold materials, solid biodegradable bioactive glass and tricalcium phosphate granules alongside solid ...
Olli-Pekka Lappalainen, Sakari S. Karhula, Marianne Haapea, Sami Kauppinen, Mikko Finnilä, Simo Saarakkala, Willy Serlo, George K. Sándor   +7 more
doaj   +1 more source

Comparative histological and histomorphometric results of six biomaterials used in two-stage maxillary sinus augmentation model after 6-month healing [PDF]

, 2018
To evaluate the performances of six different bone substitute materials used as graft in maxillary sinus augmentation by means of histological and histomorphometric analysis of bone biopsies retrieved from human subjects after a 6-month healing period ...
Cristalli, MARIA PAOLA, Iezzi, Giovanna, LA MONACA, Gerardo, Pranno, Nicola, Sfasciotti, Gian Luca, Vozza, Iole   +5 more
core   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source