Results 71 to 80 of about 1,073,868 (281)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Diabetic Calcaneal Osteomyelitis: Outcomes Before and After the Introduction of Bone Graft Substitutes—A Retrospective Cohort Study

Diabetology
Background: Calcaneal osteomyelitis is a severe form of diabetic foot osteomyelitis associated with poor healing, major amputation, and increased mortality. Evidence on the use of bone graft substitutes in this setting remains limited.
Roberto Da Ros, Enrica Barro, Andrea Michelli, Roberta Assaloni, Barbara Brunato, Marta Nardi, Cesare Miranda   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Review Article: Bone Transplantation and Immune Response

Journal of Orthopaedic Surgery, 2009
Bone is the second most common transplant tissue after blood, with the iliac crest autologous graft being most used. Bone transplantation induces osteogenesis to repair bone defects.
Hamid Shegarfi, Olav Reikeras
doaj   +1 more source

Aspergillus fumigatus biofilm formation on different bone substitutes used in maxillary sinus augmentation: an in vitro analysis

International Journal of Implant Dentistry, 2019
Background Fungus ball (FB) typically affects healthy adults, and Aspergillus fumigatus is the most frequent etiologic agent: iatrogenic factors represent an important issue in FB pathogenesis. Moreover, a recent study suggested a significant association
Claudio Stacchi, Veronica Del Lupo, Federico Berton, Teresa Lombardi, Raffaela Bressan, Roberto Di Lenarda, Cristina Lagatolla   +6 more
doaj   +1 more source

Synthetic bone graft substitutes

, 2001
Replacement of extensive local bone loss is a significant clinical challenge. There are a variety of techniques available to the surgeon to manage this problem, each with their own advantages and disadvantages.
Graves, S., Bain, G., Moore, W.
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

BONE SUBSTITUTES EFFICACY IN HIP REPLACEMENT SURGERY: A RETROSPECTIVE STUDY

, 2013
Introduction Severe bone loss is not uncommon in hip revision surgery and bone grafts or subistitutes are often required. Although the literature report excellent results, there are few clinical trials on the outcome of bone substitutes with long ...
campana v, mariotti f, MALERBA G, PAGANO ED, DONATI F, LOGROSCINO G   +5 more
core   +1 more source

Bilateral maxillary sinus floor augmentation with tissue-engineered autologous osteoblasts and demineralized freeze-dried bone

Contemporary Clinical Dentistry, 2015
The pneumatization of the maxillary sinus often results in a lack of sufficient alveolar bone for implant placement. In the last decades, maxillary sinus lift has become a very popular procedure with predictable results.
Aashish Deshmukh, Rinku Kalra, Shruti Chhadva, Angad Shetye   +3 more
doaj   +1 more source