Results 121 to 130 of about 64,693 (183)

Adult‐Onset Central Nervous System Erdheim–Chester Disease Successfully Treated With Cladribine and Cytarabine: Case Report and Literature Review

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Erdheim–Chester disease (ECD) is a rare histiocytic disorder with heterogeneous clinical manifestations. Central nervous system (CNS) involvement is associated with poor prognosis. Although targeted therapies have improved outcomes in patients with mitogen‐activated protein kinase (MAPK) pathway alterations, optimal treatment strategies for ...
Naoki Watanabe, Hajime Yasuda, Midori Ishii, Norihide Izumi, Ayaka Goto, Tadaaki Inano, Yuji Tomizawa, Taku Hatano, Miki Ando   +8 more
wiley   +1 more source

Synchrotron‐Based Deep Learning Network of the Inner Ear: Development and Expert Validation

The Laryngoscope, Volume 136, Issue 10, Page 4209-4218, October 2026.
A deep learning network to automatically segment the inner ear from preoperative clinical scans was developed using synchrotron‐radiation phase contrast imaging (SR‐PCI). On an unseen test set, the network significantly outperformed seven expert otologists/radiologists, the mean expert segmentation, and a simultaneous truth and performance level ...
Ashley Micuda, Kyle Rioux, Luke Helpard, Munir Demir Bajin, Zahra Kassam, Sachin Pandey, Jaehyun Hwang, Griselda T. Romero‐Sanchez, Manas Sharma, Lorne S. Parnes, Hanif M. Ladak, Sumit K. Agrawal   +11 more
wiley   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Herbal Formula AC591 Protects Against Cisplatin‐Induced Hearing Loss by Inhibiting p53‐Mediated Ferroptosis

Smart Medicine, Volume 5, Issue 5, October 2026.
AC591 and its core active component 18β‐glycyrrhetinic acid effectively alleviate cisplatin‐induced ototoxicity by binding p53 and suppressing p53‐mediated ferroptosis, representing promising agents for preventing cisplatin‐related hearing loss. ABSTRACT Cisplatin is a widely utilized chemotherapeutic agent for the treatment of malignant cancers ...
Yunhao Wu, Yu Tao, Lin Wei, Qiuping Liu, Jiaxin Liu, Wen Jiang, Weiwei Shi, Peng Cao, Xiaolong Fu, Cheng Cheng   +9 more
wiley   +1 more source

IGF‐1/SLC25A33 Maintains Blood‐Labyrinth Barrier Integrity by Suppressing TGF‐β/Smad2‐Mediated Pericyte Activation in Age‐Related Hearing Loss

Aging Cell, Volume 25, Issue 10, October 2026.
IGF‐1/SLC25A33–TGF‐β/Smad2 axis can regulate pericyte activation and BLB integrity, which may be a potential therapeutic target for preserving hearing in ARHL. ABSTRACT Age‐related hearing loss (ARHL) is a prevalent sensory disorder in the elderly, yet the molecular mechanisms underlying cochlear aging remain incompletely understood. While insulin‐like
Rui Xu, Jia Tang, Huan Lin, Qi Li, Yajin Feng, Xiaorong Zhang, Xiaohong Hu, Jiacai Yang, Yuhong Li, Yang Bai   +9 more
wiley   +1 more source

The Development of the Ear of Rabbit Embryo

Siriraj Medical Journal, 2004
The ear consists of three parts which are different origin but function as one unit. The internal ear originates from the surface ectoderm covering the lateral sides of myelencephalon at the fourth week.
Jantima Roongruangchai, Kajee Pilakasiri, Noppadon Sangjan, Mana Phongchapo, Kasem Koedpuech, Nutchaya Amonmattajit   +5 more
doaj  

Hepatocyte Growth Hormone Receptor Ablation Is Associated With Aging Phenotypes and Hepatic Mitochondrial Dysfunction

Aging Cell, Volume 25, Issue 10, October 2026.
Hepatocyte‐specific GHR ablation is associated with hepatic and age‐related pathologies, triggering adipose‐liver crosstalk via elevated circulating GH and subsequent CD36‐dependent hepatic steatosis. This loss impairs STAT5b phosphorylation and enhances PPARγ nuclear activation, upregulating Pdk4 and Cd36 to drive mitochondrial dysfunction and ectopic
Kangkang Yang, Yuli Jian, Fusheng Pang, Ming Ying, Qian Yang, Nian Liu, Shujing Wang, Yingjie Wu   +7 more
wiley   +1 more source

Endocranial anatomy of the earliest Cretaceous European neosuchian crocodyliform Pholidosaurus purbeckensis provides new evidence for the ecological evolution of Pholidosauridae

Journal of Anatomy, Volume 249, Issue 4, Page 787-802, October 2026.
We present new insights into the internal cranial anatomy of the neosuchian crocodyliform Pholidosaurus purbeckensis, based on CT‐scan data of material from the lowermost Cretaceous Purbeck Limestone Group, southern UK. From the study of the endocast, we obtained new information on the phylogeny and the ecological evolution of the Family ...
Leonardo Barbini, Paul M. J. Burke, Ilaria Caddeo, Marco Romano, Philip D. Mannion   +4 more
wiley   +1 more source

Bony labyrinth of Carnivora (Mammalia): the significance of phylogeny and the sensorial adaptation to aquatic environments

, 2016
International audienceThe bony labyrinth is an osseous structure surrounding the inner ear, a primary sensorial organ involved in hearing, body perception in space, and balance in vertebrates.
Grohé, Camille, Boistel, Renaud, Tseng, Z Jack, Lebrun, Renaud, Flynn, John J   +4 more
core  

The bony labyrinth of toothed whales reflects both phylogeny and habitat preferences. [PDF]

Sci Rep, 2018
Costeur L, Grohé C, Aguirre-Fernández G, Ekdale E, Schulz G, Müller B, Mennecart B.   +6 more
europepmc   +1 more source