Results 141 to 150 of about 77,306 (289)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Translation approaches to support systemic anti-cancer therapy consent for individuals with limited English proficiency. [PDF]

Support Care Cancer
Hibbs SP, Nizam R, Tanzim U, Aiken L, Habib S, Hodgson S, Williams J, Januszewski A, Hantel A, Uddin MS, Isaacs T, Bajaj B, Cockburn O, Islam A, Pratt G, Federici FM.   +15 more
europepmc   +1 more source

Program disclosure booklet and participation agreement. 2015: Mar. 31.

, 2007
Title from PDF t.p. (viewed Jan. 10, 2008).; "November 5, 2007."; Accompanied by "Supplement no. 1 dated November 5, 2007, to the Connecticut Higher Education Trust Program disclosure booklet dated November 5, 2007" (2 p. : digital, PDF file)
Connecticut Higher Education Trust.
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Healthcare providers' awareness of a mobile-based app for disease classification in northwest Ethiopia: A multilevel logistic regression analysis. [PDF]

PLoS One
Jemere AT, Yilma TM, Gezie LD, Mengiste SA, Gullslett MK, Kaasbøll JJ, Tilahun B.   +6 more
europepmc   +1 more source

Notecard and booklet on "Lunar Surface Exploration"

Copyright ownership of the speech transcript booklet and photographs within is unknown. Contact an archivist for more information.
Armstrong, Neil A., 1930-2012
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Booklet

, 1930
Booklet regarding the advantages offered by Dallas as the headquarters for Southern Air ...
Chamber of Commerce (Dallas, Tex.)
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Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Evaluation of the relevance, acceptability, and adaptability of an existing healthy lifestyle program for people living with HIV. [PDF]

BMC Public Health
Hill J, Skinner D, Goedecke JH, van Rensburg R, Van Schalkwyk M, Nachega J, Kengne AP.   +6 more
europepmc   +1 more source