Results 41 to 50 of about 1,156,059 (330)
Scientific Reports, 2022 Transfection of tumor suppressor miRNAs such as miR-34a, miR-449a, and miR-16 with DNA damage can regulate apoptosis and senescence in cancer cells. miR-16 has been shown to influence autophagy in cervical cancer. However, the function of miR-34a and miR-
Shantanu Gupta +7 more
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Identification of dynamic driver sets controlling phenotypical landscapes
Computational and Structural Biotechnology Journal, 2022 Controlling phenotypical landscapes is of vital interest to modern biology. This task becomes highly demanding because cellular decisions involve complex networks engaging in crosstalk interactions.
Silke D. Werle +9 more
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Control of complex networks requires both structure and dynamics [PDF]
, 2015 The study of network structure has uncovered signatures of the organization of complex systems. However, there is also a need to understand how to control them; for example, identifying strategies to revert a diseased cell to a healthy state, or a mature
Gates, Alexander J., Rocha, Luis M.
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Optimal control for probabilistic Boolean networks
IET Systems Biology, 2010 Aberrant gene functions usually contribute to the pathology or diseases. Avoiding undesirable cellular phenotypes as many as possible is a major purpose of external control for gene regulatory networks. An interesting question is how to control a gene network subjected to the condition that the genes reach some undesirable states with minimal ...
Q, Liu, X, Guo, T, Zhou
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CANA: A Python Package for Quantifying Control and Canalization in Boolean Networks
Frontiers in Physiology, 2018 Logical models offer a simple but powerful means to understand the complex dynamics of biochemical regulation, without the need to estimate kinetic parameters.
Rion B. Correia +6 more
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Construction and Control of Genetic Regulatory Networks: A Multivariate Markov Chain Approach [PDF]
, 2008 In the post-genomic era, the construction and control of genetic regulatory networks using gene expression data is a hot research topic. Boolean networks (BNs) and its extension Probabilistic Boolean Networks (PBNs) have been served as an effective tool ...
Chan, RH +4 more
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Chaos control in random Boolean networks by reducing mean damage percolation rate
, 2010 Chaos control in Random Boolean networks is implemented by freezing part of the network to drive it from chaotic to ordered phase. However, controlled nodes are only viewed as passive blocks to prevent perturbation spread.
Gershenson C +7 more
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Validation of Gene Regulatory Network Inference Based on Controllability
Frontiers in Genetics, 2013 There are two distinct issues regarding network validation: (1) Does an inferred network provide good predictions relative to experimental data? (2) Does a network inference algorithm applied within a certain network model framework yield networks that ...
Edward eDougherty, Xiaoning eQian
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Identification of periodic attractors in Boolean networks using a priori information.
PLoS Computational Biology, 2022 Boolean networks (BNs) have been developed to describe various biological processes, which requires analysis of attractors, the long-term stable states.
Ulrike Münzner +4 more
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Optimal Control of Probabilistic Boolean Networks: An Information-Theoretic Approach
IEEE Access, 2021 The primary challenge with biological sciences is to control gene regulatory networks (GRNs), thereby creating therapeutic intervention methods that alter network dynamics in the desired manner.
K. Sonam +3 more
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