Modeling and controlling the two-phase dynamics of the p53 network: a Boolean network approach
Although much empirical evidence has demonstrated that p53 plays a key role in tumor suppression, the dynamics and function of the regulatory network centered on p53 have not yet been fully understood.
Guo-Qiang Lin +4 more
doaj +1 more source
Accelerating Boolean implications with FPGAs [PDF]
We present the FPGA implementation of an algorithm [4] that computes implications between signal values in a boolean network. The research was performed as a masterrsquos thesis [5] at the University of Frankfurt.
Kunz, Wolfgang +2 more
core
A stochastic and dynamical view of pluripotency in mouse embryonic stem cells
Pluripotent embryonic stem cells are of paramount importance for biomedical research thanks to their innate ability for self-renewal and differentiation into all major cell lines.
Hufton, Peter G. +3 more
core +3 more sources
Repository of logically consistent real-world Boolean network models
Recent developments in both computational analysis and data-driven synthesis enable a new era of automated reasoning with logical models (Boolean networks in particular) in systems biology.
Samuel Pastva +4 more
semanticscholar +1 more source
Stable Imitation of Multigait and Bipedal Motions for Quadrupedal Robots Over Uneven Terrains
How are quadrupedal robots empowered to execute complex navigation tasks, including multigait and bipedal motions? Challenges in stability and real‐world adaptation persist, especially with uneven terrains and disturbances. This article presents an imitation learning framework that enhances adaptability and robustness by incorporating long short‐term ...
Erdong Xiao +3 more
wiley +1 more source
Matrix formalism to describe functional states of transcriptional regulatory systems. [PDF]
Complex regulatory networks control the transcription state of a genome. These transcriptional regulatory networks (TRNs) have been mathematically described using a Boolean formalism, in which the state of a gene is represented as either transcribed or ...
Erwin P Gianchandani +4 more
doaj +1 more source
Parameter Learning of Probabilistic Boolean Control Networks with Input-Output Data
Article Parameter Learning of Probabilistic Boolean Control Networks with Input-Output Data Hongwei Chen 1,*, Qi Chen 1, Bo Shen 1, and Yang Liu 2 1 College of Information Science and Technology, Donghua University, Shanghai 201620, China 2 School of ...
Hongwei Chen +3 more
semanticscholar +1 more source
PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao +16 more
wiley +1 more source
On the Origins of Toughness in Corymbia calophylla (Marri Tree) Nuts
We uncover the natural toughening mechanisms of the marri nut, including fiber pullout, crack deflection, and a viscoelastic matrix, which enable exceptional energy absorption and ductility comparable to Teflon, with an elastic modulus similar to acrylic.
Wegood M. Awad +7 more
wiley +1 more source
Predictive Model and Soft Sensors Application to Dynamic Process Operative Control
As amply acknowledged, operational errors can be identified as one of the most common cause of plant equipment deterioration, consequently the operational control exerts a determining role in managing and slowing down the effects of aging and enhancing ...
Tomaso Vairo +4 more
doaj +1 more source

