Construction and Control of Genetic Regulatory Networks: A Multivariate Markov Chain Approach [PDF]
, 2008 In the post-genomic era, the construction and control of genetic regulatory networks using gene expression data is a hot research topic. Boolean networks (BNs) and its extension Probabilistic Boolean Networks (PBNs) have been served as an effective tool ...
Chan, RH +4 more
core +1 more source
A Boolean network control algorithm guided by forward dynamic programming.
PLoS ONE, 2019 Control problem in a biological system is the problem of finding an interventional policy for changing the state of the biological system from an undesirable state, e.g. disease, into a desirable healthy state.
Mohammad Moradi +2 more
doaj +1 more source
Robust Control Invariance of Probabilistic Boolean Control Networks via Event-Triggered Control
IEEE Access, 2018 This paper investigates the robust control invariance of probabilistic Boolean control networks via the technique of semi-tensor product. Some essential conditions are obtained to check whether the set is a robust event-triggered control invariant set ...
Liyun Tong +5 more
doaj +1 more source
Detectability of Delayed Boolean Control Networks Based on Full-Order Observer
IEEE Access, 2021 This paper investigates the detectability of delayed Boolean control networks (DBCNs) via the Boolean semi-tensor product (BSTP) method. Firstly, three concepts of weak detectability, strong detectability, and detectability for DBCNs are proposed and the
Wenrong Li +3 more
doaj +1 more source
Finding optimal control policy in probabilistic Boolean networks with hard constraints by using integer programming and dynamic programming [PDF]
, 2010 Session 2 regularIn this paper, we study control problems of Boolean Networks (BNs) and Probabilistic Boolean Networks (PBNs). For BN CONTROL, by applying external control, we propose to derive the network to the desired state within a few time steps ...
Akutsu, T, Chen, X, Ching, WK, Tamura, T
core +1 more source
Robust Invariant Set Analysis of Boolean Networks
Complexity, 2019 In this paper, the robust invariant set (RIS) of Boolean (control) networks with disturbances is investigated. First, for a given fixed point, consider a special set called immediate neighborhoods of the fixed point; then a discrete derivative of Boolean
Bowen Li +3 more
doaj +1 more source
On the Criticality of Adaptive Boolean Network Robots
Entropy, 2022 Systems poised at a dynamical critical regime, between order and disorder, have been shown capable of exhibiting complex dynamics that balance robustness to external perturbations and rich repertoires of responses to inputs.
Michele Braccini +3 more
doaj +1 more source
Therapeutic target discovery using Boolean network attractors: avoiding pathological phenotypes [PDF]
, 2014 Target identification, one of the steps of drug discovery, aims at identifying biomolecules whose function should be therapeutically altered in order to cure the considered pathology.
Boissel, Jean-Pierre, Poret, Arnaud
core +5 more sources
Scalable Control of Asynchronous Boolean Networks [PDF]
, 2019 We summarise our recent research results on developing efficient and scalable control methods for gene regulatory networks modelled as asynchronous Boolean networks. Our methods compute a minimal subset of nodes of a given Boolean network, such that (different types of) perturbations of these nodes, in one step or a sequence of steps, can drive the ...
Su, Cui, Paul, Soumya, Pang, Jun
openaire +2 more sources
Output Regulation of Boolean Control Networks With Nonuniform Sampled-Data Control
IEEE Access, 2019 This paper investigates the output regulation problem of Boolean control networks by nonuniform sampled-data control, where the sampling period is aperiodic.
Lin Lin +4 more
doaj +1 more source