Results 51 to 60 of about 14,268 (264)
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Lightweight design of excavator working device based on automatically generated surrogate model
Scientific ReportsTo address the conservative excavator working device configuration obtained by traditional design methods, a lightweight structure design method was proposed in this study based on automatically generated surrogate model.
He Zhang +4 more
doaj +1 more source
Irrigation dimensioning of reel machines with water distribution systems: gun and boom with emitters
Cuadernos del CURIHAM, 2020 The reel machines irrigation technique has expanded in recent years thanks to the technological improvements that have been introduced. Several investigations have been carried out regarding the effectiveness of the irrigation of this equipment with “gun”
Esequiel Rolando Jiménez Espinosa
doaj +1 more source
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Analysis of loading of the boom of a dragline excavator
Горное оборудование и электромеханикаThe article discusses a method for determining the forces acting on the elements of the boom of a dragline excavator when the bucket is in position, both in the stretch zone and at other points in the working area.
Brozovsky S.Yu. +3 more
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Rigid-flexible Coupling Analysis of Backhoe Hydraulic Excavator Working Device
E3S Web of Conferences, 2018 This paper develops a rigid-flexible coupling approach to predict the dynamic performance of the excavator, including the stress distribution and stress diagram of curves.
Yuan Yongliang
doaj +1 more source
Design and Production of a Knuckle Boom Crane
, 2021 MAS150
Borge, Henrik +2 more
openaire +1 more source