Results 51 to 60 of about 21,439 (303)
Satirical Game Design: The Case of the Boardgame Construction BOOM!
International Conference on the Foundations of Digital Games, 2020 To recognize satire, the audience must be aware of the context and the satirical intent of the work in question. Academic research on the possibilities and effects of satire in games is minimal, if compared with other rhetorical uses of playful interaction.
Schellekens, Jasper +4 more
openaire +2 more sources
Unstructured Grids for Sonic Boom Analysis and Design [PDF]
53rd AIAA Aerospace Sciences Meeting, 2015 An evaluation of two methods for improving the process for generating unstructured CFD grids for sonic boom analysis and design has been conducted. The process involves two steps: the generation of an inner core grid using a conventional unstructured grid generator such as VGRID, followed by the extrusion of a sheared and stretched collar grid through ...
Richard L. Campbell +2 more
openaire +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Vibration absorber optimization for boom-sprayer
Przegląd Naukowy Inżynieria i Kształtowanie Środowiska, 2019 The main task of this work is to analyze optimal design-system of the booms of boom-sprayers. The discrete-continue models of machines dynamics of such wheeled machines as boom-sprayer with elongated boom element with the attachment of dynamic vibration ...
Ivan Kernytskyy +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
Numerical solution of critical force of n-step telescopic boom with superlift device
AIP Advances, 2023 The installation of a superlift device on the telescopic boom of a crane is the main method to improve the stress condition of the telescopic boom and to effectively improve the lifting performance of the crane.
Fenglin Yao +4 more
doaj +1 more source
Design of a GOSSAMER-1 type boom deployment mechanism with increased boom root stiffness
, 2021 This thesis deals with the further development of a boom deployment mechanism with integrated boom root deployment. Current deployment mechanisms have a lack of stiffness due to the so-called transition zone, where the boom cannot unfold its entire cross-
Henkies, Patrick, Straubel, Marco
core
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source