Results 51 to 60 of about 224,408 (267)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Explainable AI-based feature importance analysis for ovarian cancer classification with ensemble methods

Frontiers in Public Health
IntroductionOvarian Cancer (OC) is one of the leading causes of cancer deaths among women. Despite recent advances in the medical field, such as surgery, chemotherapy, and radiotherapy interventions, there are only marginal improvements in the diagnosis ...
Ashwini Kodipalli, Ashwini Kodipalli, V. Susheela Devi, Shyamala Guruvare, Taha Ismail   +4 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Quantum Boosting

CoRR, 2020
37 pages; v2: minor edits to improve ...
Srinivasan Arunachalam, Reevu Maity
openaire   +3 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Boosting Barlow Twins Reduced Order Modeling for Machine Learning‐Based Surrogate Models in Multiphase Flow Problems

Water Resources Research
We present an innovative approach called boosting Barlow Twins reduced order modeling (BBT‐ROM) to enhance the reliability of machine learning surrogate models for multiphase flow problems.
T. Kadeethum, V. L. S. Silva, P. Salinas, C. C. Pain, H. Yoon   +4 more
doaj   +1 more source

Comparing Person-Specific and Independent Models on Subject-Dependent and Independent Human Activity Recognition Performance

Sensors, 2020
The distinction between subject-dependent and subject-independent performance is ubiquitous in the human activity recognition (HAR) literature. We assess whether HAR models really do achieve better subject-dependent performance than subject-independent ...
Sebastian Scheurer, Salvatore Tedesco, Brendan O’Flynn, Kenneth N. Brown   +3 more
doaj   +1 more source

Investigating the Effect of Process-based Instruction of Writing on the IELTS Writing Task Two Performance of Iranian EFL Learners: Focusing on Hedging & Boosting

Cogent Education, 2021
The instruction of metadiscourse markers to L2 writers has been recommended by some scholars to assist them in employing a certain tone in persuading readers.
Mojgan Firoozjahantigh, Ebrahim Fakhri Alamdari, Amir Marzban   +2 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source