Results 71 to 80 of about 370,101 (314)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Phoneme and sentence-level ensembles for speech recognition [PDF]

, 2011
We address the question of whether and how boosting and bagging can be used for speech recognition. In order to do this, we compare two different boosting schemes, one at the phoneme level and one at the utterance level, with a phoneme-level bagging ...
Dimitrakakis, Christos, Bengio, Samy, Samy Bengio, Dimitrakakis, Christos,, Bengio, S., Christos Dimitrakakis   +5 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Estimation and Regularization Techniques for Regression Models with Multidimensional Prediction Functions [PDF]

, 2008
Boosting is one of the most important methods for fitting regression models and building prediction rules from high-dimensional data. A notable feature of boosting is that the technique has a built-in mechanism for shrinking coefficient estimates and
Potapov, Sergej, Pfahlberg, Annette, Hothorn, Torsten, Schmid, Matthias   +3 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Kernel classifier construction using orthogonal forward selection and boosting with Fisher ratio class separability measure [PDF]

, 2006
A greedy technique is proposed to construct parsimonious kernel classifiers using the orthogonal forward selection method and boosting based on Fisher ratio for class separability measure.
Wang, X. X., Harris, C. J., X. Hong, Wang, X.X., Hong, X., S. Chen, C.J. Harris, X.X. Wang, Harris, C.J., Chen, S.   +9 more
core   +1 more source

Boosting Barlow Twins Reduced Order Modeling for Machine Learning‐Based Surrogate Models in Multiphase Flow Problems

Water Resources Research
We present an innovative approach called boosting Barlow Twins reduced order modeling (BBT‐ROM) to enhance the reliability of machine learning surrogate models for multiphase flow problems.
T. Kadeethum, V. L. S. Silva, P. Salinas, C. C. Pain, H. Yoon   +4 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Binary and Ordinal Random Effects Models Including Variable Selection [PDF]

, 2010
A likelihood-based boosting approach for fitting binary and ordinal mixed models is presented. In contrast to common procedures it can be used in high-dimensional settings where a large number of potentially influential explanatory variables is available.
Groll, Andreas, Tutz, Gerhard
core   +1 more source

Ensemble Machine Learning Approach for Parkinson’s Disease Detection Using Speech Signals

Mathematics
The detection of Parkinson’s disease (PD) is vital as it affects the population worldwide and decreases the quality of life. The disability and death rate due to PD is increasing at an unprecedented rate, more than any other neurological disorder.
Syed Nisar Hussain Bukhari, Kingsley A. Ogudo   +1 more
doaj   +1 more source