Results 81 to 90 of about 839,459 (306)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Hammering diagnosis algorithm with automated calibration

Nihon Kikai Gakkai ronbunshu, 2016
The hammering test has been widely used for inspection of social infrastructures because of its accuracy and efficiency of operation. In order to automate and apply the method to actual inspection sites, it is important for the system to calibrate itself
Hiromitsu FUJII, Atsushi YAMASHITA, Hajime ASAMA   +2 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Quantum Boosting

CoRR, 2020
37 pages; v2: minor edits to improve ...
Srinivasan Arunachalam, Reevu Maity
openaire   +3 more sources

Genetic and Psychosocial Predictors of Aggression: Variable Selection and Model Building With Component-Wise Gradient Boosting

Frontiers in Behavioral Neuroscience, 2018
Rationale: Given datasets with a large or diverse set of predictors of aggression, machine learning (ML) provides efficient tools for identifying the most salient variables and building a parsimonious statistical model.
Robert Suchting, Joshua L. Gowin, Charles E. Green, Consuelo Walss-Bass, Scott D. Lane, Scott D. Lane   +5 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Transformer-Based Ensemble Learning for Symptom-Level Classification and DSM-5-Oriented Depression Screening on Social Media

Information
Depression screening from social media has increasingly benefited from transformer-based architectures; however, integrating symptom-level analysis with clinically grounded diagnostic screening remains challenging. This study proposes a unified two-phase
Jandara Suksam, Piya Kaewbuadee, Chatklaw Jareanpon   +2 more
doaj   +1 more source

Therapeutic potential of NAD-boosting molecules: the in vivo evidence

Cell Metabolism, 2018
Summary Nicotinamide adenine dinucleotide (NAD), the cell’s hydrogen carrier for redox enzymes, is well known for its role in redox reactions. More recently, it has emerged as a signaling molecule. By modulating NAD+ sensing enzymes, it controls hundreds
Luis A. Rajman, K. Chwalek, D. Sinclair
semanticscholar   +1 more source