Results 91 to 100 of about 461,725 (268)

POST study on Pharmacogenetics

Technikfolgenabschätzung – Theorie und Praxis, 2001
D. Cope, P. Border
doaj   +1 more source

Awareness and Perceived Risk Factors of Chronic Kidney Disease Among Patients with Diabetes in the Northern Borders of Saudi Arabia: Implications for a Strategic Monitoring and Management Plan

Diseases
Background/Objectives: Chronic kidney disease (CKD) poses a significant health burden for individuals with diabetes mellitus, increasing morbidity and mortality.
Safya E. Esmaeel, Altaf Saleh Mahdi Alanazi Alnzi, Nouf Mofareh Mulahed Alanazi, Rose Dahi Khamis Alanazi, Amal Mohammed Shahi Alruwaili, Areeb Rawaf Mohammed Alanzi, Ahad Wadi Alnagzi Alanazi, Yousef Wasmi Alenezi, Ahmed Saleh Alanazi, Rimas Khalid A. Alanazi, Baraah Abu Alsel, Eslam K. Fahmy, Manal S. Fawzy   +12 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Exploring Awareness Levels of Diabetic Ketoacidosis Risk Among Patients with Diabetes: A Cross-Sectional Study

Clinics and Practice
Background/Objectives: Diabetic ketoacidosis (DKA) is a critical complication of diabetes mellitus, posing significant health. While global studies have indicated a concerning lack of awareness regarding DKA among patients with diabetes, research ...
Elhassan Hussein Eltom, Abdulrahman Omar A. Alali, Rakan Khalid Marzouq Alanazi, Ali Ahmad M. Alanazi, Meshal Ahmed Abdullah Albalawi, Saud Alraydh N. Alanazi, Mansour Sarhan G. Alanazi, Abdelnaser A. Badawy, Naglaa Mokhtar, Manal S. Fawzy   +9 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The impact of after-hours messaging on job stress and burnout among Taiwan’s border police: the roles of social support and coping strategies

Humanities & Social Sciences Communications
With the advancement of technology, communication software is increasingly facilitating interaction between organizations and employees. However, its unrestricted accessibility often blurs the line between work and personal life.
Nein-Tsu Chiang, Rui-Hsin Kao, Hsiang-Yu Ma, Cheng-Chung Cho   +3 more
doaj   +1 more source

Analytical Solutions for the Nonlinear Stochastic Fractional KdV Equation: An application of the Generalized Riccati Equation Mapping Method

Journal of Applied Science and Engineering
The article examines the fractional stochastic Korteweg-de Vries (FSKdV) equation, with a focus on space-time white noise and conformable fractional derivatives (CFD).
Abaker A. Hassaballa, Ali Satty, Mohyaldein Salih, Ahmed M. A. Adam, Omer M. A. Hamed, Zakariya M. S. Mohammed, Ashraf F. A. Mahmoud, Elzain A. E. Gumma   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source