Results 111 to 120 of about 2,308,949 (362)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Awareness and Perceived Risk Factors of Chronic Kidney Disease Among Patients with Diabetes in the Northern Borders of Saudi Arabia: Implications for a Strategic Monitoring and Management Plan

Diseases
Background/Objectives: Chronic kidney disease (CKD) poses a significant health burden for individuals with diabetes mellitus, increasing morbidity and mortality.
Safya E. Esmaeel, Altaf Saleh Mahdi Alanazi Alnzi, Nouf Mofareh Mulahed Alanazi, Rose Dahi Khamis Alanazi, Amal Mohammed Shahi Alruwaili, Areeb Rawaf Mohammed Alanzi, Ahad Wadi Alnagzi Alanazi, Yousef Wasmi Alenezi, Ahmed Saleh Alanazi, Rimas Khalid A. Alanazi, Baraah Abu Alsel, Eslam K. Fahmy, Manal S. Fawzy   +12 more
doaj   +1 more source

The Strategic Issues of Economic Development of Border Area of Indonesia - Malaysia [PDF]

, 2016
On the land, Indonesia is bordered by three countries: Malaysia, Papua New Guinea and Timor Leste.Whereas, in Indonesia sea area bordered by 10 countries: India, Malaysia, Singapore, Thailand,Vietnam, Philippines, the Republic of Palau, Australia, East ...
Sudaryono, S. (Sudaryono), Sunarya, A. (Abas)   +1 more
core  

A Survey and Research on Language Usage in Border Counties of Ethnic Minorities in China [PDF]

, 2022
Xin Lin
openalex   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Epidemiological features of travel-related cases Mpox (Monkeypox) cases detected at airports in Pakistan; Insights from Screening Surveillance

International Journal of Infectious Diseases
Background: The 2022 multi-country outbreak of Monkeypox virus (Mpox) was declared as PHEIC. Pakistan reported five human Mpox cases in travelers returning to Pakistan filtered at the points of entry (airports) through entry screening.
Dr Nadia Noreen
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

EFFECT OF BREAKFAST ON BODY MASS INDEX (BMI) IN MALE CHILDREN IN NORTHERN BORDER REGION SAUDI ARABIA

Khyber Medical University Journal, 2014
OBJECTIVE: to determine the effect of regular homemade breakfast on body mass index (BMI) of school going male children in Northern region of Saudi Arabia.
Shehab Ahmed Alenazi, Hafeezullah Wazir Ali, Othman Meshfi Alshammary, Mohammad Sari Al Enazi, Farmanullah Gul Nawaz Wazir   +4 more
doaj  

Exploring Awareness Levels of Diabetic Ketoacidosis Risk Among Patients with Diabetes: A Cross-Sectional Study

Clinics and Practice
Background/Objectives: Diabetic ketoacidosis (DKA) is a critical complication of diabetes mellitus, posing significant health. While global studies have indicated a concerning lack of awareness regarding DKA among patients with diabetes, research ...
Elhassan Hussein Eltom, Abdulrahman Omar A. Alali, Rakan Khalid Marzouq Alanazi, Ali Ahmad M. Alanazi, Meshal Ahmed Abdullah Albalawi, Saud Alraydh N. Alanazi, Mansour Sarhan G. Alanazi, Abdelnaser A. Badawy, Naglaa Mokhtar, Manal S. Fawzy   +9 more
doaj   +1 more source