Results 81 to 90 of about 1,273,770 (305)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Corporate Acquisitions and Firm-level Uncertainty: Domestic versus Cross-Border Deals [PDF]

open access: yes, 2020
This paper studies the impact of corporate acquisitions on the uncertainty faced by acquiring firms. We use data for UK public companies from 2004 to 2017 and employ a matching estimator combined with difference-in-differences to control for the ...
Bai, Y., Girma, S., Riaño, A.
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Transit Migration in Armed Conflicts: New Trends and Challenges for International Policy

open access: yesDve Domovini
This study analyzes the transformation of migration routes and volumes through transit states and the resulting challenges for international policy amid armed conflicts.
Lyudmila Korigova   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

The Enemy at the Gates: International Borders, Migration and Human Rights

open access: yesLaws, 2013
This article considers contemporary border management regimes from a human rights perspective. It demonstrates how a preoccupation with border controls and enforcement has led to serious concerns for the safety and protection of migrants. As border zones
Pia Oberoi, Eleanor Taylor-Nicholson
doaj   +1 more source

Border guards as an alien police: usages of the Schengen Agreement in France [PDF]

open access: yes
The creation of a common European space following the integration of the Schengen Agreement into the acquis communautaires through the Amsterdam Treaty in 1997, and the subsequent treaties and summits, lead Member States to consider border control as a ...
Sara Casella Colombeau
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The Nexus of FTFs Counterterrorism Strategy, Immigration Control, and Border Security Through Indonesia's Migration Policy

open access: yesJurnal Ilmiah Kebijakan Hukum
This study employs a single case study to build an initial understanding of a case or an evaluation of a fatal attack by Uzbekistan detainees affiliated with a terrorist group to the immigration office at the North Jakarta Immigration Office.
Yanos Okterano, Heru Susetyo
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

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