Results 41 to 50 of about 239,970 (262)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The modified mRNA vaccine protects immunocompromised AG129 mice from lethal challenge and multi-tissue infection by Zika virus

Emerging Microbes and Infections
The multiple epidemics of Zika virus (ZIKV) posed a substantial threat to public health. Clinical evidence suggests that ZIKV could break through the blood–brain, blood-placenta, and blood-testis barriers, leading to severe outcomes such as congenital ...
Yuhuan Yan, Junbin Wang, Hao Yang, Yun Yang, Longhai Yuan, Cong Tang, Yanan Zhou, Qing Huang, Wenhai Yu, Xiaoming Liang, Dongdong Lin, Yanwen Li, Xuena Du, Yuxia Yuan, Rui Peng, Jiali Xu, Zhaolan Guo, Wenhao Xie, Wenqi Quan, Hongyu Chen, Jian Zhou, Shuaiyao Lu, Xiaozhong Peng   +22 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Development of a colloidal gold immunochromatographic strip for the rapid detection of fowl adenovirus serotype 4 using prepared penton protein-specific monoclonal antibodies

Frontiers in Veterinary Science
Fowl adenovirus serotype 4 (FAdV-4) is the primary pathogen responsible for hydropericardium-hepatitis syndrome (HHS) and is associated with high mortality rates (20–80%) in 3–6-week-old chickens.
Sisi Luo, Sisi Luo, Bingyi Yang, Jiaoling Huang, You Wei, Zhixun Xie, Xiaofeng Li, Aiqiong Wu, Zhihua Ruan, Sheng Wang, Yanfang Zhang, Meng Li, Liji Xie, Ming Yan, Weiwei Wang, Ping Wei   +15 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Epidemiological investigation and genomic characterization of Gyrovirus galga1 in Guangxi, China

Poultry Science
Gyrovirus galga1 (GyG1), an emerging pathogen within the Anelloviridae family, exhibits expanding host diversity and zoonotic potential, yet its epidemiological patterns and genomic determinants remain poorly characterized.
Dan Yu, Yanfang Zhang, Zhixun Xie, Sisi Luo, Liji Xie, Meng Li, Tingting Zeng, Qing Fan, Minxiu Zhang, Xiaofeng Li, You Wei, Aiqiong Wu, Lijun Wan   +12 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Ageing and the border between health and disease [PDF]

European Respiratory Journal, 2014
Ageing is associated with a progressive degeneration of the tissues, which has a negative impact on the structure and function of vital organs and is among the most important known risk factors for most chronic diseases. Since the proportion of the world’s population aged >60 years will double in the next four decades, this will be accompanied by an
William, MacNee, Roberto A, Rabinovich, Gourab, Choudhury   +2 more
openaire   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source