Results 71 to 80 of about 447,397 (301)

Consumer Confidence at an All-Time Low in New Hampshire 2/19/2009 [PDF]

, 2009
Consumer confidence in New Hampshire is at record lows and residents have become increasingly pessimistic about both the state’s and the country’s economic ...
Survey Center, UNH
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Teorie (mexicko‑americké) hranice: Mestické vědomí Glorie Anzaldúy [PDF]

Gender a Výzkum, 2012
Border theory, an interdisciplinary approach to the analysis of cultures located (especially) on the U.S.-Mexican border, was to a great extent initiated by the publication of Gloria Anzaldúa’s multigenre masterpiece Borderlands/La Frontera – The New ...
Tereza Jiroutová Kynčlová
doaj  

Stereotypical Representations of the Border Space in some Mexican Fictions about Tijuana

Catedral Tomada: Revista de Crítica Literaria Latinoamericana, 2019
The city of Tijuana, the quintessential archetype for thinking the social and cultural dynamics of life on the border, has been described and represented to the point of exhaustion in literature.
Felipe Oliver
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Frontline mobilisation as border thinking: redefining just transitions through decolonial praxis and community organising

Global Social Challenges Journal
I analyse the coming together of frontline actors, particularly people of colour in the US, building on the concept of ‘just transitions’ to help solve the climate crisis as ‘border thinking or border epistemology’ within decolonial thought.
Cleovi C. Mosuela
doaj   +1 more source

Reimagining the liminal Cerrado: the virtual ancestral future

Ecology and Society
This paper examines transformations in social-ecological system through the process-relational perspective (PRP), using the concepts of the “real-possible,” the existing reality, and the “actual-virtual” potentials that exist beyond current hegemonic ...
Taís Sonetti-González, María Mancilla García, Tilman Hertz, Ana Paula D Aguiar   +3 more
doaj   +1 more source

Materialese as Border Thinking: The Multimodal Voice of Bilingual Learning Materials

Voces y Silencios: Revista Latinoamericana de Educación, 2019
This paper discusses the emerging and multidimensional category in a study about the development of a didactic material for Spanish learning in bilingual and multimodal settings. Since didactic materials for L2 education seemed to rely on geopolitics of
Yeraldine Aldana
doaj   +1 more source