Results 91 to 100 of about 531,551 (280)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Borderline

Singular Sociais e Humanidades, 2019
O presente trabalho visa a apresentação de um caso Borderline, com ênfase na organização do funcionamento psíquico, na dinâmica familiar e interações sociais, através do método de Rorschach e da abordagem sistêmica. O método utilizado foi o clínico qualitativo com estudo de caso e foram priorizados os dados associados à perturbação da identidade e a ...
  +5 more sources

Comparing Correlates of Quality of Life in Borderline and Average Intellectual Functioning

Annals of Indian Psychiatry
Background: Borderline intellectual functioning (BIF) is associated with deficits in cognitive functions and effective communication or interpersonal skills, impacting socio-occupational functioning in adulthood.
Geetesh Kumar Singh, Aarzoo Gupta, Shivangi Mehta   +2 more
doaj   +1 more source

COLA II - Radio and Spectroscopic Diagnostics of Nuclear Activity in Galaxies [PDF]

, 2002
We present optical spectroscopic observations of 93 galaxies taken from the infra-red selected COLA (Compact Objects in Low Power AGN) sample. The sample spans the range of far-IR luminosities from normal galaxies to LIRGs.
A. Marston, A. Zezas, C. A. Heisler, Clavel J., de Grijp M. H. K., E. A. Corbett, Efstathiou A., Fairall A. P., Fairall A. P., Gardner F. F., Hagiwara Y., Heckman T., Heisler C. A., Keel W. C., Knappen J. H., L. Kewley, Laurent O., M. A. Dopita, Martin J. M., P. N. Appleton, R. P. Norris, V. Charmandaris   +21 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Histopathological Study of Ovarian Tumors at a Tertiary Care Hospital of Central Nepal

Journal of College of Medical Sciences-Nepal, 2019
Background: Ovarian tumors are histogenetically varied and complex tumors spanning all age groups. They account for 30% of all gynaecologic cancers. Malignant tumors carry a high mortality due to its late detection and ineffective screening programs ...
Binita Goyal, T Sheshagiri Rao, Himanshu Regmi   +2 more
doaj   +1 more source

Borderline Aggregation Kinetics in ``Dry'' and ``Wet'' Environments

, 1995
We investigate the kinetics of constant-kernel aggregation which is augmented by either: (a) evaporation of monomers from finite-mass clusters, or (b) continuous cluster growth -- \ie, condensation. The rate equations for these two processes are analyzed
B. R. Thompson, C. M. Sorensen, D. ben-Avraham, D. Beysens, D. Kessler, E. M. Hendriks, F. Family, H. Takayasu, J. D. Murray, J. L. Spouge, K. Kang, L. Peliti, M. Aizenman, M. H. Ernst, M. H. Ernst, P. J. Blatz, P. L. Krapivsky, P. Meakin, R. D. Vigil, R. M. Ziff, S. K. Friedlander, S. Redner, S. Redner, T. E. Ramabhadran, T. M. Rogers, W. H. White   +25 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

An Evaluation of Georgia's HOPE Scholarship Program: Impact on College Attendance and Performance [PDF]

, 1998
pending
Daniel T. Buglar, Gary T. Henry
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source