Results 31 to 40 of about 14,077 (253)

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

The ultrasound features of borderline ovarian tumors

肿瘤影像学, 2016
Objective: To explore the sonographic features of borderline ovarian tumors, and to evaluate the value of ultrasound in the diagnosis of borderline ovarian tumors. Methods: The data of 114 patients who underwent surgical treatment and were diagnosed with
GUI Yang, DAI Qing
doaj  

Invasive Recurrence of an Intestinal-Type Mucinous Epithelial Neoplasm of Low Malignant Potential: Case Report and Review of the Literature

Case Reports in Oncology, 2011
Pseudomyxoma peritonei is only rarely seen in conjunction with primary ovarian tumors. It has been suggested that only ruptured mucinous tumors arising in ovarian mature cystic teratomas can result in this clinical picture.
S. Cosyns, M. Leyder, C. Bourgain, P. De Sutter   +3 more
doaj   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Anaplastic carcinoma in ovarian seromucinous cystic tumor of borderline malignancy

Journal of Ovarian Research, 2018
Background The mortality rate of ovarian cancer is the highest among all gynecological malignancies in Japan. Ovarian tumors are classified as benign, borderline malignant, or malignant.
Toshiyuki Okumura, Etuo Muronosono, Masahiko Tsubuku, Yasuhisa Terao, Satoru Takeda, Masanori Maruyama   +5 more
doaj   +1 more source

A cross-sectional study of immunohistochemical evaluation of surface epithelial ovarian tumors

MGM Journal of Medical Sciences, 2022
Background: Ovarian cancer is one of the most common malignancies in female patients. In recent years, immunohistochemistry (IHC) has emerged as an important tool in the diagnosis of ovarian tumors.
Vikas Pandey, Jyotirmayee Mishra, Pralhad S Potdar   +2 more
doaj   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Development and Validation of Differential Diagnosis Models and Nomograms Based on Serum D-Dimer and Other Multimodal Information for Borderline and Benign Epithelial Ovarian Tumors: A Multicenter Study

Diagnostics
Background: It is difficult to make a definite diagnosis of borderline epithelial ovarian tumors before surgery. In order to avoid incorrectly classifying tumors as benign, a differential diagnosis model was developed to distinguish between benign and ...
Yiqing Zhang, Yayang Duan, Fang He, Chunhua Duan, Junli Wang, Chaoxue Zhang, Yi Zhou   +6 more
doaj   +1 more source

Human telomerase reverse transcriptase expression in ovarian tumors

Indian Journal of Pathology and Microbiology, 2012
Background : Ovarian cancer is the 6 th most common cancer among women. In ovarian tumors, the borderline category is not well defined due to the difficulty in assessing stromal invasion. The World Health Organization (WHO) defined it as tumor that lacks
Awadh Ali Makhashen Maraei, Ahmad Zailani Hatta, Mohd Sidik Shiran, Geok Chin Tan   +3 more
doaj   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source