CD44v6 is associated with tumor aggressiveness and chemoresistance in bladder cancer [PDF]
Scientific ReportsBladder cancer is a fast-moving and recurrent malignancy where survival hinges on early detection and precise risk stratification. The search for robust biomarkers is urgent, and CD44v6 has emerged as a compelling candidate.
Iris Lodewijk +20 more
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Demethylating therapy increases cytotoxicity of CD44v6 CAR-T cells against acute myeloid leukemia [PDF]
Frontiers in Immunology, 2023 BackgroundCD44v6 chimeric antigen receptor T (CD44v6 CAR-T) cells demonstrate strong anti-tumor ability and safety in acute myeloid leukemia (AML). However, the expression of CD44v6 on T cells leads to transient fratricide and exhaustion of CD44v6 CAR-T ...
Fankai Meng
exaly +4 more sources
Engineering Modular Half-Antibody Conjugated Nanoparticles for Targeting CD44v6-Expressing Cancer Cells [PDF]
Nanomaterials, 2021 Gastric cancer (GC) remains a major cause of death worldwide mainly because of the late detection in advanced stage. Recently, we proposed CD44v6 as a relevant marker for early detection of GC, opening new avenues for GC-targeted theranostics.
Bianca N Lourenço +2 more
exaly +4 more sources
Biomedicines, 2021 In gastric cancer (GC), biomarkers that define prognosis and predict treatment response remain scarce. We hypothesized that the extent of CD44v6 membranous tumor expression could predict prognosis and therapy response in GC patients.
Gabriela M Almeida +19 more
doaj +2 more sources
CD44v6 expression in non-anaplastic thyroid carcinoma: characterization of candidates for targeted therapy [PDF]
Thyroid ResearchBackground CD44v6 is a membranous antigen upregulated in solid tumors and a promising molecular radiotherapy target, especially in anaplastic thyroid carcinoma (ATC). A Phase 1 trial recently launched to evaluate the lutetium-labeled anti-CD44v6 antibody
Adam Stenman +6 more
doaj +2 more sources
CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway. [PDF]
PLoS ONE, 2011 Identification of stem cell-like brain tumor cells (brain tumor stem-like cells; BTSC) has gained substantial attention by scientists and physicians. However, the mechanism of tumor initiation and proliferation is still poorly understood.
Mayumi Jijiwa +14 more
doaj +3 more sources
Chimeric Antigen Receptor (CAR)-NK92 cells effective against glioblastoma, breast- and pancreatic cancer in vitro and in a murine xenograft model of ovarian cancer [PDF]
Cancer Cell InternationalBackground Aggressive tumors such as glioblastoma, breast, ovarian and pancreatic cancer have low survival rates and new therapies are urgently needed.
Abdelhadi Boulifa +4 more
doaj +2 more sources
Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the predictive value of the expression of CD44v6 and EGFR on the efficacy of neoadjuvant chemotherapy (NACT) in stageⅡ-Ⅲ cervical cancer.
MAO Wanli +11 more
doaj +1 more source
CD44v6 chimeric antigen receptor T cell specificity towards AML with FLT3 or DNMT3A mutations
Clinical and Translational Medicine, 2022 Background Chimeric antigen receptor T‐cell (CAR‐T) therapy for acute myeloid leukaemia (AML) has thus far been elusive, in part due to target restriction and phenotypic heterogeneity of AML cells.
Ling Tang +16 more
doaj +1 more source
International Journal of Breast Cancer, 2021 Background. Invasive breast carcinoma of no special type (IBC-NST) is the most widespread invasive carcinoma subtype causing primarily regional metastases of the lymphatic node (LNM).
Primariadewi Rustamadji +2 more
doaj +1 more source