Results 41 to 50 of about 4,511 (199)

Beyond a Metabolite: Lactylation as a Pivotal Regulator of Colorectal Cancer Pathogenesis and Treatment Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao, Yun Liang, Xinwen Liang, Qisheng Su, Xiaohong Li   +4 more
wiley   +1 more source

Expression of CD44V6-containing isoforms influences cisplatin response in gastric cancer cells [PDF]

, 2020
CD44v6-containing isoforms are frequently de novo expressed in gastric cancer (GC). Whether CD44v6 has a central role in GC transformation and/or progression, whether it conditions response to therapy or whether it is only a bystander marker is still not
Pereira, C, Oliveira, C, Daniel Ferreira, Pedro L. Granja, Carla Oliveira, Almeida, GM, Ferreira, D, Carla Pereira, Granja, PL, Mendes, N, Nuno Mendes, Gabriela M. Almeida   +11 more
core   +1 more source

Expression of CIP2A and CD44v6 in condyloma acuminatum-involved skin and its correlation with patients' prognosis

Pifu-xingbing zhenliaoxue zazhi
Objective To investigate the expression levels of cancerous inhibitor of protein phosphatase 2A (CIP2A) and CD44v6 in condyloma acuminatum (CA)-involved skin and to analyze the correlation between their expression and the distribution of HPV genotypes in
ZHANG Yijie, YANG Can, LIN Yongli
doaj   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, Volume 4, Issue 3, August 2026.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

CD44v6 controls Met internalization.

, 2013
(A) Left side: HeLa cells were transfected either with a pool of control siRNAs or a mixture of two different CD44v6 specific siRNAs and starved for 24 hours (Material and Methods). The cells were biotinylated (0,5 mg/ml), induced with HGF (50 ng/ml) and
Susanne Hasenauer (405490), Giuseppina Pace (405493), Véronique Orian-Rousseau (405495), Dieter Malinger (405491), David Koschut (405492), Alexandra Matzke (405494), Anja von Au (194847)   +6 more
core   +1 more source

Generation and evaluation of antibody agents for molecular imaging of CD44v6-expressing cancers

, 2017
Aim: The aim of this study was to generate and characterize scFv antibodies directed to human CD44v6, as well as to radiolabel and evaluate top candidates in vitro and in vivo for their potential use in CD44v6-targeted molecular imaging in cancer ...
Nestor, Marika, Ronny Falk, Mortensen, Anja, Velikyan, Irina, Nilvebrant, Johan, Nestor, Marika,, Haylock, Anna-Karin, Anja Mortensen, Haylock, Anna-Karin,, Velikyan, Irina,, Irina Velikyan, Falk, Ronny, Nilvebrant, Johan,, Anna-Karin Haylock, Mortensen, Anja,, Falk, Ronny,, Marika Nestor, Johan Nilvebrant   +17 more
core   +1 more source

Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6 [PDF]

, 2015
CD44v6, a member of the CD44 family of transmembrane glycoproteins is a co-receptor for two receptor tyrosine kinases (RTKs), Met and VEGFR-2 (vascular endothelial growth factor receptor 2).
Koschut, D., Karathanasis, Christos, Heilemann, M., Niemann, Hartmut H., Koschut, David, Dietz, Marina, Volz, Yvonne, Niemann, H. H., Richert, Ludovic, Matzke-Og, Alexandra, Mély, Yves, Niemann, Hartmut ; https://orcid.org/, Volz, Y., Karathanasis, C., Richert, L., Dietz, M. S., Orian-Rousseau, Véronique, Matzke-Ogi, Alexandra, Matzke-Ogi, A., Wagner, Moritz G., Wagner, M. G., Orian-Rousseau, V., Dietz, Marina S., Heilemann, Mike, Mély, Y.   +24 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, Volume 16, Issue 7, Page 1414-1427, July 2026.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, Volume 20, Issue 6, Page 1556-1590, June 2026.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

SFN upregulated CD44v6 expression in U87MG and U373MG cells.

, 2014
We treated the cells with SFN (20 µM) without or with PD98059 (25 µM) for 24 h. Western blot showed that SFN significantly upregulated CD44v6 expression. After PD98059 and SFN were added into the medium, CD44v6 expression was reduced significantly versus
Chunliu Li (284115), Hua Tian (220297), Yan Zhou (6523), Jing Niu (528781), Lianlian Du (284117), Wei Wu (27708), Xiaohui Peng (528779), Gaoxiang Yang (528780)   +7 more
core   +1 more source