Results 51 to 60 of about 4,511 (199)

Interplay Between Chemotherapy-Activated Cancer Associated Fibroblasts and Cancer Initiating Cells Expressing CD44v6 Promotes Colon Cancer Resistance

Frontiers in Oncology, 2022
Cancer-initiating cells (CICs) drive colorectal tumor growth by their supportive niches where CICs interact with multiple cell types within the microenvironment, including cancer-associated fibroblasts (CAFs).
Shibnath Ghatak, Shibnath Ghatak, Vincent C. Hascall, Nikos Karamanos, Roger R. Markwald, Suniti Misra, Suniti Misra   +6 more
doaj   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas

Heliyon, 2023
Aim: The aim of this study was to assess the feasibility of targeted therapy of thyroid carcinoma, first exploring potential targets BRAF, EGFR and CD44v6 in patient material through immunohistochemistry and mutation analysis.
A.C.L. Mortensen, J. Imgenberg-Kreuz, D. Spiegelberg, J. Botling, M. Nestor   +4 more
doaj   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, Volume 9, Issue 5, Page 914-931, May 2026.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

CD44v6 Dependence of Premetastatic Niche Preparation by Exosomes

Neoplasia, 2009
The metastasizing capacity of the rat pancreatic adenocarcinoma BSp73ASML (ASML(wt)) is strikingly reduced by a knockdown of CD44v4-v7 (ASML(kd)). We used this model to analyze the role of the CD44 variant isoform (CD44v) in (pre)metastatic niche formation. Intrafootpad injections of ASML(wt)-, but not ASML(kd)-conditioned medium (CM), strongly promote
Thorsten Jung, Donatello Castellana, Pamela Klingbeil, Ines Cuesta Hernández, Mario Vitacolonna, David J. Orlicky, Steve R. Roffler, Pnina Brodt, Margot Zöller   +8 more
openaire   +3 more sources

CAR T Cells Redirected to CD44v6 Control Tumor Growth in Lung and Ovary Adenocarcinoma Bearing Mice

Frontiers in Immunology, 2020
The main challenge of adoptive therapy with Chimeric Antigen Receptor modified T cells (CAR T) is the application to the field of solid tumors, where the identification of a proper antigen has emerged as one of the major drawbacks to CAR T cell treatment
Simona Porcellini, Claudia Asperti, Stefano Corna, Eleonora Cicoria, Veronica Valtolina, Anna Stornaiuolo, Barbara Valentinis, Claudio Bordignon, Catia Traversari   +8 more
doaj   +1 more source

Nomogram Incorporating CD44v6 and Clinicopathological Factors to Predict Lymph Node Metastasis for Early Gastric Cancer. [PDF]

PLoS ONE, 2016
Treatment strategy for early gastric cancer depends on the probability of lymph node metastasis. The aim of this study is to develop a nomogram predicting lymph node metastasis in early gastric cancer using clinicopathological factors and biomarkers.A ...
Bang Wool Eom, Jungnam Joo, Boram Park, Min Jung Jo, Seung Ho Choi, Soo-Jeong Cho, Keun Won Ryu, Young-Woo Kim, Myeong-Cherl Kook   +8 more
doaj   +1 more source

TYRO3, AXL, MERTK and Their Ligands in Brain Metastases From Colorectal Cancers

Cancer Medicine, Volume 15, Issue 5, May 2026.
TYRO3, AXL, and MERTK are expressed in primary tumors and extra‐cerebral and brain metastases from colorectal cancers. AXL, primarily expressed in endothelial cells, is the more conserved marker between primary tumor and brain metastasis. The Low AXL/High GAS6 ratio is of poor prognosis in metastatic colorectal cancer patients.
Anaïs Noblanc, Fatima Dkhissi, Pierre‐Olivier Guichet, Lucie Lebeau, Serge Milin, Sheik Emambux, Pauline Roussille, Camille Evrard, Lucie Karayan‐Tapon, David Tougeron, Omar Benzakour, Violaine Randrian   +11 more
wiley   +1 more source

CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma

Frontiers in Immunology, 2023
Head and neck squamous cell carcinoma (HNSCC) is a major challenge for current therapies. CAR-T cells have shown promising results in blood cancers, however, their effectiveness against solid tumors remains a hurdle. Recently, CD44v6-directed CAR-T cells
Ioana Sonya Ciulean, Joe Fischer, Andrea Quaiser, Christoph Bach, Hinrich Abken, Uta Sandy Tretbar, Stephan Fricke, Ulrike Koehl, Ulrike Koehl, Dominik Schmiedel, Dominik Schmiedel, Thomas Grunwald   +11 more
doaj   +1 more source

Integrating oncolytic adenoviruses into combination cancer therapy: Mechanisms, advances and clinical outlook

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Oncolytic adenoviruses synergise with chemotherapy, radiotherapy and immunotherapy to enhance anti‐tumour efficacy. Chemotherapy and radiotherapy increase tumour susceptibility and antigen release through DNA damage, while immunotherapy restores T‐cell activity.
Vlad Iova, Gilda Mihaela Iova, Mihail Silviu Tudosie, Ioana Scrobota, Catalin Gabriel Smarandache   +4 more
wiley   +1 more source