Results 61 to 70 of about 4,511 (199)

Targeting CD44v6, a co-receptor for Met and VEGFR-2 in endothelial cells, inhibits tumour angiogenesis [PDF]

, 2009
Isoformen der Transmembran-Glykoproteinfamilie CD44, die die Sequenz des varianten Exons v6 enthalten, können als Ko-Rezeptoren für die Rezeptortyrosinkinase Met in Epithelzellen dienen.
Tremmel, Martina
core   +1 more source

Immunohistochemical Study for CD44v6 in Hepatocellular Carcinoma and Cholangiocarcinoma

Cancer Research and Treatment, 2002
CD44 is a multifunctional adhesion molecule in cell-to-cell and cell-to-matrix interactions. This transmembrane glycoprotein exists in either standard or variant form, with the variation originating in alternative splicing. This study was designed to evaluate the role of CD44v6, one of the CD44 isoforms, in hepatocellular carcinoma and ...
Ki Jung, Yun, Kwon Ha, Yoon, Weon Cheol, Han   +2 more
openaire   +2 more sources

Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer

Drug Delivery, 2021
Oxaliplatin resistance is one of the main causes of failed colorectal cancer treatment, followed by recurrence and metastasis. In this study, we found that colorectal cancer cells secrete a high level of hyaluronic acid (HA), which interacts with its ...
Wenlong Du, Xiaoping Yang, Shenfu He, Jia Wang, Yuanxian Guo, Bangguo Kou, Yongjie Jiang, Pan Bian, Bingtai Li, Lanning Yin   +9 more
doaj   +1 more source

CircRSU1 Activates the hnRNPA1/HIF‐1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma

Advanced Science, Volume 13, Issue 22, 17 April 2026.
This study reveals circRSU1 with important oncogenic roles in hepatocellular carcinoma (HCC). CircRSU1, highly abundant in HCC, interacts with and stabilizes hnRNPA1 from ubiquitination and degradation. This stabilization facilitates hnRNPA1 binding to the internal ribosome entry site of HIF1A to increase HIF‐1α protein translation.
Shuting Xue, Danduo Wei, Yongzhi Zhao, Jinchang Pan, Hanyuan Zhang, Niya Liu, Jianjuan Zhang, Jiaxin Liu, Jianping Jin, Mu Xiao, Xinhua Feng, Aifu Lin, Lei Zhao, Stephanie Roessler, Junfang Ji   +14 more
wiley   +1 more source

A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis

, 2009
A specific splice variant of the CD44 cell- surface protein family, CD44v6, has been shown to act as a coreceptor for the receptor tyrosine kinase c-Met on epithelial cells.
Ponta, Helmut, Tremmel, Martina, Tremmel, M., Albrecht, I., Laib, A. M., H. Ponta, V. Olaku, Olaku, Vivienne, Olaku, V., Augustin, H. G., Laib, Anna M., Matzke, Alexandra, A. Matzke, K. Ballmer-Hofer, M. Heroult, H. G. Augustin, V. Orian-Rousseau, Christofori, Gerhard, Héroult, Mélanie, A. M. Laib, Ponta, H., G. Christofori, Matzke, A., Orian-Rousseau, Véronique, M. Tremmel, Christofori, G., Ballmer-Hofer, Kurt, I. Albrecht, Ballmer-Hofer, K., Augustin, Hellmut G., Heroult, M., Orian-Rousseau, V., Albrecht, Imke   +32 more
core   +1 more source

CD44v6, a target for novel antibody treatment approaches, is frequently expressed in multiple myeloma and associated with deletion of chromosome arm 13q

Haematologica, 2005
BACKGROUND AND OBJECTIVES: Despite recent advances in the treatment of multiple myeloma (MM), this disease remains incurable in the majority of patients. Therefore, innovative treatment strategies are mandatory.
P Liebisch, S Eppinger, C Schopflin, G Stehle, G Munzert, H Dohner, M Schmid   +6 more
doaj  

Effects of Tumor Microenvironment on Lung Cancer Stem Cells: Bidirectional Regulatory Mechanisms

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Lung cancer, with a high mortality rate, poses challenges in treatment due to its invasiveness and heterogeneity. Lung cancer stem cells (LCSCs) are considered key contributors to recurrence and metastasis because of their self‐renewal, pluripotency, and drug resistance.
Hongyi Lai, Ruihang Luo, Wei Zou, Xuyang Liu, Maosen Liu, Mingshan Liu, Jingtao Zhang   +6 more
wiley   +1 more source

CD44H and CD44V6 Expression in Different Subtypes of Hodgkin Lymphoma [PDF]

Modern Pathology, 2000
CD44 is a broadly distributed family of cell surface glycoproteins. The expression of CD44H has been documented in both Hodgkin lymphoma and non-Hodgkin lymphoma. CD44V6 has been associated with more aggressive behavior in non-Hodgkin lymphoma, but such a correlation has not been established in Hodgkin lymphoma.
F, Anwar, B L, Wood
openaire   +2 more sources

Clinicopathological Analysis of the Expression of CD44v6 in Primary Thyroid Cancer and Recurrent Regional Lymph Nodes [PDF]

, 2007
Although the prognosis of differentiated thyroid cancer is generally favorable, some patients develop progressive disease resulting in a life-threatening condition and occasionally fatal outcome.
Maeda, Shigeto, Uga, Tatsuya, Furui, Junichiro, Iwata, Tohru, Kanematsu, Takashi   +4 more
core   +1 more source

Cancer Hallmarks Expression in Oral Leukoplakia: Systematic Review and Meta‐Analysis

Oral Diseases, Volume 32, Issue 2, Page 322-337, February 2026.
ABSTRACT Objectives To assess the available evidence on the expression of hallmarks of cancer and oral leukoplakia (OL) malignant transformation probability, with the goal of identifying the earliest oncogenic molecular events participating in oral cancer carcinogenesis.
I. González‐Ruiz, P. Ramos‐García, H. Boujemaoui‐Boulaghmoudi, N. Mjouel‐Boutaleb, M. A. González‐Moles   +4 more
wiley   +1 more source