Results 81 to 90 of about 4,511 (199)
CD44v6 as innovative sarcoma target for CAR-redirected CIK cells
OncoImmunology, 2018 Purpose of our study was to explore a new immunotherapy for high grade soft tissue sarcomas (STS) based on cytokine-induced killer cells (CIK) redirected with a chimeric antigen receptor (CAR) against the tumor-promoting antigen CD44v6.
V. Leuci +15 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: The prognostic power of the levels of total CD44 and its isoform CD44v6 for patients with gastric cancer (GC) remains controversial. Therefore, our study aims to generalize the clinicopathological and prognostic significance of these two
Min Fang +6 more
doaj +1 more source
, 2008 Despite recent advances in the treatment of multiple myeloma (MM), this disease remains incurable in the majority of patients. Therefore, innovative treatment strategies are mandatory.
Amrhein, Susanne
core +1 more source
, 2020 The main challenge of adoptive therapy with Chimeric Antigen Receptor modified T cells (CAR T) is the application to the field of solid tumors, where the identification of a proper antigen has emerged as one of the major drawbacks to CAR T cell treatment
Veronica Valtolina (8395743) +8 more
core +1 more source
Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma
Mediators of Inflammation, 2016 Nitrative and oxidative DNA damage plays an important role in inflammation-related carcinogenesis. To investigate the involvement of stem cells in Epstein-Barr virus infection-related nasopharyngeal carcinoma (NPC), we used double immunofluorescence ...
Shumin Wang +9 more
doaj +1 more source
, 2020 The main challenge of adoptive therapy with Chimeric Antigen Receptor modified T cells (CAR T) is the application to the field of solid tumors, where the identification of a proper antigen has emerged as one of the major drawbacks to CAR T cell treatment
Veronica Valtolina (8395743) +8 more
core +1 more source
Zhongguo shiyan zhenduanxue, 2009 目的在本研究中检测63例结直肠癌组织中CD44v6的表达情况,以评估CD44v6在结直肠肿瘤发生发展过程中的作用。方法采用HE染色,光镜,和免疫组化方法,观察不同病程阶段、不同病变范围的结直肠癌对细胞粘附分子CD44v6不同的表达情况。结果63例肿瘤组织标本中,对CD44v6表达有24例强阳性,13例阳性（中度染色）,26例阴性。CD44v6的阴性或阳性表达（中度染色）与肿瘤大小 ...
李滨 +4 more
doaj
Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia
, 2018 Key PointsThe spleen but not bone marrow microenvironment induces CD44v6 variants in CLL, which promote early engraftment. CD44v6 expression is linked to NF-κB and MAPK signaling in murine and human B-cell leukemia and contributes to proliferation.
Gutjahr, Julia C. +31 more
core +1 more source
, 2020 The main challenge of adoptive therapy with Chimeric Antigen Receptor modified T cells (CAR T) is the application to the field of solid tumors, where the identification of a proper antigen has emerged as one of the major drawbacks to CAR T cell treatment
Veronica Valtolina (8395743) +8 more
core +1 more source
Meta-analysis of prognostic and clinical significance of CD44v6 in esophageal cancer
, 2015 CD44v6 is a cell adhesion molecule that plays an important role in the development and progression of esophageal cancer. However, the prognostic value and clinical significance of CD44v6 in esophageal cancer remains controversial.
Hu, Bangli +5 more
core +1 more source