Results 71 to 80 of about 4,511 (199)

CD44v6 is internalized upon HGF induction.

, 2013
(A) Left side: Lysates of HT29, HeLa and HepG2 cells were immunoprecipitated with the CD44v6 antibody (VFF18) and subjected to SDS-PAGE. The blots were probed with the same antibody. Apparent MW is indicated.
Susanne Hasenauer (405490), Giuseppina Pace (405493), Véronique Orian-Rousseau (405495), Dieter Malinger (405491), David Koschut (405492), Alexandra Matzke (405494), Anja von Au (194847)   +6 more
core   +1 more source

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source

Knockdown of CD44v6 with siRNA transfection in YCC-2 cell line and overexpression of CD44v6 with plasmid transfection in MKN-28 cell line.

, 2016
Knockdown of CD44v6 with siRNA transfection in YCC-2 cell line and overexpression of CD44v6 with plasmid transfection in MKN-28 cell line.
Boram Park (625962), Soo-Jeong Cho (189658), Young-Woo Kim (189693), Jungnam Joo (29049), Bang Wool Eom (696711), Min Jung Jo (2902386), Seung Ho Choi (739177), Keun Won Ryu (189680), Myeong-Cherl Kook (189663)   +8 more
core   +1 more source

Cancer Stem Cells in Human Gastrointestinal and Hepatic Cancers

MedComm, Volume 6, Issue 12, December 2025.
Gastrointestinal cancer stem cells obtain the ability of unlimited self‐renewal, drug resistance, tumorigenicity as well as tendency of metastasis. ABSTRACT Gastrointestinal cancers, including gastric, hepatic, and colorectal cancers, represent a major public health problem globally. Although the 5‐year survival rate of gastrointestinal tumors has been
Jiawen Bu, Mingming Cui, Yu Zhang, Yu Lu, Xudong Zhu, Fu Peng, Hong Zhang   +6 more
wiley   +1 more source

Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR

Advanced Science, Volume 12, Issue 38, October 13, 2025.
The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen, Marie Lafitte, Maud Barbery, Kevin Espie, Maya Jeitany, Romain Larive, Jihane Vitre, Conception Paul, Yvan Boublik, Elise Fourgous, Valérie Simon, Audrey Sirvent, Madeline Neiveyans, Steeve Thirard, Lucile Bansard, Morgan Maillard, Nathalie Coutry, Jacques Colinge, Philippe Jay, Pierre Martineau, Michael Hahne, Julie Pannequin, Serge Roche   +22 more
wiley   +1 more source

자궁경부암에서 CD44v6 단백의 발현

, 1997
CD44 is a cell-surface glycoprotein postulated to play a role in tumor cell metastasis. Aberrant expression of the cell adhesion molecule CD44 has been detected in human tumors and the expression of specific isoforms(splice variants) has been shown to be
양, 현원, 유, 희석, 장, 기홍, 오, 기석, 주, 희재, 정, 태영   +5 more
core   +1 more source

Resveratrol: Sensitising CD44+ Cervical Cancer Cells to Carboplatin and Mitigating Metastasis

Cancer Medicine, Volume 14, Issue 17, September 2025.
Resveratrol reduces metastasis and EMT by inhibiting aberrant signaling pathways, promoting E‐cadherin transcription, and reducing mesenchymal marker expression (vimentin, N‐cadherin, and slug). In addition, it inhibits E6/E7 oncoproteins and reduces CSC/CD44 levels in the tumor microenvironment, enhancing carboplatin sensitivity and reducing drug ...
Cayleigh de Sousa, Carla Eksteen, Anna‐Mart Engelbrecht   +2 more
wiley   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, Volume 12, Issue 30, August 14, 2025.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis [PDF]

, 2014
Cancer stem cells drive tumor formation and metastasis, but how they acquire metastatic traits is not well understood. Here, we show that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation ...
Biffoni, Mauro, De Maria, Ruggero, CATALANO, VERONICA, Catalano, V, BENFANTE, Antonina, Biffoni, M, Gaspare Gulotta, De Maria Marchiano, Ruggero, Matilde Todaro, Sperduti, I, STASSI, Giorgio, APUZZO, TIZIANA, Mauro Biffoni, Francesco Dieli, GULOTTA, Gaspare, Gaggianesi, M, TODARO, Matilde, De Maria, R, GAGGIANESI, MIRIAM, DIELI, Francesco, Apuzzo, T, Volpe, S, Iovino, F, Ruggero De Maria, Gianfranco Cocorullo, VOLPE, SILVIA, COCORULLO, Gianfranco, SPERDUTI, ISABELLA, Giorgio Stassi, Iovino, Flora, Flora Iovino   +30 more
core   +1 more source

PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment

MedComm, Volume 6, Issue 8, August 2025.
The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang, Ke Zhang, Zhenwang Zhang, Xinran Zeng, Zihang Huang, Peizhuo Qin, Zhilin Xie, Xue Cai, Milad Ashrafizadeh, Yu Tian, Ruqiong Wei   +10 more
wiley   +1 more source