Results 21 to 30 of about 4,511 (199)
Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins. [PDF]
PLoS ONE, 2013 Receptor Tyrosine Kinases (RTKs) are involved in many cellular processes and play a major role in the control of cell fate. For these reasons, RTK activation is maintained under tight control.
Susanne Hasenauer +6 more
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Expression of Bmi-1, P16, and CD44v6 in Uterine Cervical Carcinoma and Its Clinical Significance
Cancer Biology & Medicine, 2012 Objective: Bmi-1, a putative proto-oncogene, is a core member of the polycomb gene family, which is expressed in many human tumors. The p16 protein negatively regulated cell proliferation, whereas CD44v6 is associated with proliferation as an important ...
Mei-ying Weng +3 more
doaj +2 more sources
Zhongshan Daxue xuebao. Yixue kexue ban, 1998 目的 观察分析 CD44v6在口腔鳞癌原发组织和转移组织中的表达,以期明确 CD44v6 在口腔鳞癌淋巴道转移 中的作用。方法: 免疫组织化学染色、半定量评估染色强度和测算阳性染色细胞后统计分析。结果: CD44v6 分子在正常口腔 粘膜上皮基底层、基底上层、棘层细胞胞膜表达; 不同部位口腔粘膜上皮的阳性表达模式基本一致。在口腔鳞癌原发组织中, CD44v6 表达减弱,表现为阳性反应产物形态的改变和 CD44v6阳性细胞数明显少于正常组织(P
doaj +1 more source
CD44v6 engages in colorectal cancer progression [PDF]
Cell Death & Disease, 2019 AbstractCD44 is a transmembrane glycoprotein. When the CD44 gene is expressed, its pre-messenger RNA (mRNA) can be alternatively spliced into mature mRNAs that encode several CD44 isoforms. The mRNA assembles with ten standard exons, and the sixth variant exon encodes CD44v6, which engages in a variety of biological processes, including cell growth ...
Lixin Ma, Lihua Dong, Pengyu Chang
openaire +2 more sources
High Dual Expression of the Biomarkers CD44v6/α2β1 and CD44v6/PD-L1 Indicate Early Recurrence after Colorectal Hepatic Metastasectomy [PDF]
, 2022 Considering the biology of CRC, distant metastases might support the identification of high-risk patients for early recurrence and targeted therapy. Expression of a panel of druggable, metastasis-related biomarkers was immunohistochemically analyzed in ...
Friederike Wrana +9 more
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The clinical significance of CD44v6 in malignant and benign primary bone tumors
BMC Musculoskeletal Disorders, 2023 Background The objective of this study was to assess the expression profile of CD44v6, a potential cancer stem cell marker, and its diagnostic and predictive significance in three distinct types of primary bone tumors.
Ameinh Hosseini +7 more
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Immunohistochemical expression of CD44v6 in differentiated thyroid carcinomas [PDF]
, 2012 BackgroundCD44 is a polymorphic family of cell surface proteoglycans and glycoproteins implicated in cell-to-cell and cell-to-matrix adhesion interactions and tumor metastasis.AimThis study was designed to histopathologically examine and ...
Tawil, Galila Haseeb El +3 more
core +1 more source
Frontiers in Oncology, 2022 Chemoresistance in colorectal cancer initiating cells (CICs) involves the sustained activation of multiple drug resistance (MDR) and WNT/β-catenin signaling pathways, as well as of alternatively spliced-isoforms of CD44 containing variable exon-6 (CD44v6)
Shibnath Ghatak +6 more
doaj +1 more source
Diagnostic accuracy of CD44V6 for osteosarcoma: a meta-analysis [PDF]
Journal of Orthopaedic Surgery and Research, 2016 Recently, more and more evidences have revealed the association between CD44V6 and osteosarcoma (OS), but whether it can be used as a clinical biomarker is still unknown. The purpose of this study is to assess the diagnostic value of CD44V6 in OS by conducting a meta-analysis.All relevant electronic literatures were collected from seven international ...
Zhang, Yunyuan +9 more
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, 2023 BackgroundCD44v6 chimeric antigen receptor T (CD44v6 CAR-T) cells demonstrate strong anti-tumor ability and safety in acute myeloid leukemia (AML). However, the expression of CD44v6 on T cells leads to transient fratricide and exhaustion of CD44v6 CAR-T ...
Yong You +25 more
core +1 more source