Results 91 to 100 of about 588 (131)

Overview of Boron Neutron Capture Therapy in 2022

Cancer Biotherapy and Radiopharmaceuticals, 2023
In April 2022, the National Cancer Institute of the United States organized a 3-day seminar, dedicated to boron neutron capture therapy (BNCT). This short article summarizes a presentation from that event, which is intended to provide an overview of activities currently underway worldwide to make BNCT available for patient treatments.
Wolfgang A.G. Sauerwein, Miha Ulčar
openaire   +2 more sources

The role of boron MRI in boron neutron capture therapy

Journal of Neuro-Oncology, 1997
Boron magnetic resonance imaging (MRI) and spectroscopy (MRS) are being developed for use in boron neutron capture therapy (BNCT). With continued development, boron MRI may be used to locate BNCT agents in vivo, evaluate the pharmacokinetics of BNCT agents, and aid in treatment planning.
G W, Kabalka, C, Tang, P, Bendel
openaire   +2 more sources

Boronated Thymidine Analogues for Boron Neutron Capture Therapy

Nucleosides, Nucleotides and Nucleic Acids, 2006
Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described.
B T S, Thirumamagal, Jayaseharan, Johnsamuel, Guirec Y, Cosquer, Youngjoo, Byun, Junhua, Yan, Sureshbabu, Narayanasamy, Werner, Tjarks, Rolf F, Barth, Ashraf S, Al-Madhoun, Staffan, Eriksson   +9 more
openaire   +2 more sources

Optimization of Boron and Neutron Delivery for Neutron Capture Therapy

Pigment Cell Research, 1989
A number of groups in the United States have received funding that will permit evaluation of the clinical efficacy of the neutron capture therapy (NCT) procedure. Various reactors are being modified to allow the construction of an epithermal neutron beam.At the Brookhaven Medical Research Reactor (BMRR), the patient irradiation facility is being ...
R G, Fairchild, D N, Slatkin, J A, Coderre, P L, Micca, B H, Laster, S B, Kahl, P, Som, I, Fand, F, Wheeler   +8 more
openaire   +2 more sources

Boron neutron capture therapy.

The British Journal of Radiology, 1997
mal or epithermal neutron irradiation. Naturallythe Petten High Flux Reactor Centre, Holland and occurring 10B has a very high affinity for thermal at the University of Helsinki, Finland. Other neutrons, having a thermal neutron cross-section European Centres, including the UK group in of 3838 barns for the 10B(n, a) 7Li reaction.
openaire   +2 more sources

Boron neutron capture therapy of a rat glioma

Neurosurgery, 1990
The purpose of the present study was to utilize a well-established rat glioma to evaluate boron neutron capture therapy for the treatment of malignant brain tumors. Boron-10 (10B) is a stable isotope which, when irradiated with thermal neutrons, produces a capture reaction yielding high linear energy transfer particles (10B + 1nth----[11B]----4He(alpha)
N R, Clendenon, R F, Barth, W A, Gordon, J H, Goodman, F, Alam, A E, Staubus, C P, Boesel, A J, Yates, M L, Moeschberger, R G, Fairchild   +9 more
openaire   +2 more sources

Boron neutron-capture therapy

Neutron News, 1990
Abstract Boron Neutron Capture Therapy (BNCT) is a method of radiation therapy based on the 10B(n,4He)7Li reaction that shows promise in the treatment of some malignant tumors of the brain and of the skin. Considerable research on neutron beam development and on the chemistry, pharmacology and toxicology of boron-containing drugs for BNCT is in ...
openaire   +1 more source

Dose prescription in boron neutron capture therapy

International Journal of Radiation Oncology*Biology*Physics, 1994
The purpose of this paper is to address some aspects of the many considerations that need to go into a dose prescription in boron neutron capture therapy (BNCT) for brain tumors; and to describe some methods to incorporate knowledge from animal studies and other experiments into the process of dose prescription.Previously, an algorithm to estimate the ...
N, Gupta, R A, Gahbauer, T E, Blue, A, Wambersie   +3 more
openaire   +2 more sources

Boron-neutron capture therapy in relation to immunotherapy

Acta Neurochirurgica, 1978
The essential feature of tumour therapy rests upon host-tumour interaction. To achieve therapeutic effects, a prerequisite to immunotherapy is the reduction of tumour cells in the host's body. Such measures should not be immunosuppressive. Cytotoxic chemotherapy is not appropriate in this regard.
H, Hatanaka, K, Amano, S, Kamano, H, Fankhauser, T, Hanamura, K, Sano   +5 more
openaire   +2 more sources

Boron Neutron Capture Therapy

2001
Boron neutron capture therapy in Japan was started by H. Hatanaka at HTR in 1968. Successively, four reactors (HTR, MuITR, KUR, and JRR-2) were authorized for medical use (Figure 1). He modified the method developed by W. Sweet. Furthermore, he decided to introduce BSH, which was discovered and tested by his coworker A. H.
openaire   +1 more source