Results 81 to 90 of about 588 (131)

Boron and gadolinium neutron capture therapy

Russian Chemical Bulletin, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Narayan Hosmane, M Takagaki
exaly   +2 more sources

Boron Neutron Capture Therapy for Cancer

Scientific American, 1990
Boron neutron capture therapy (BNCT) bring together two components that when kept separate have only minor effects on normal cells. The first component is a stable isotope of boron (boron 10) that can be concentrated in tumor cells. The second is a beam of low-energy neutrons that produces short-range radiation when absorbed, or captured, by the boron.
R F, Barth, A H, Soloway, R G, Fairchild
openaire   +3 more sources

Boron neutron capture therapy for glioblastoma

Cancer Letters, 2008
Boron neutron capture therapy (BNCT) theoretically allows the preferential destruction of tumor cells while sparing the normal tissue, even if the cells have microscopically spread to the surrounding normal brain. The tumor cell-selective irradiation used in this method is dependent on the nuclear reaction between the stable isotope of boron ((10)B ...
Tetsuya, Yamamoto, Kei, Nakai, Akira, Matsumura   +2 more
openaire   +2 more sources

Microdosimetry for Boron Neutron Capture Therapy

Radiation Research, 1992
Preclinical studies for boron neutron capture therapy (BNCT) using epithermal neutrons are ongoing at several laboratories. The absorbed dose in tumor cells is a function of the thermal neutron flux at depth, the microscopic boron concentration, and the size of the cell.
C S, Wuu, H I, Amols, P, Kliauga, L E, Reinstein, S, Saraf   +4 more
openaire   +2 more sources

Boron Neutron Capture Therapy

Physics of Atomic Nuclei, 2021
Fundamentals of boron neutron capture therapy of malignant tumors are outlined, and the current status of the development of epithermal-neutron sources on the basis of charged-particle accelerators is surveyed. Attention is additionally given to a neutron source based on a charged-particle accelerator belonging to a new type—a tandem accelerator with ...
openaire   +1 more source

Ligand Liposomes and Boron Neutron Capture Therapy

Journal of Neuro-Oncology, 2003
Boron neutron capture therapy (BNCT) has been used both experimentally and clinically for the treatment of gliomas and melanomas, with varying results. However, the therapeutic effects on micro-invasive tumor cells are not clear. The two drugs that have been used clinically, p-boronophenylalanine, (BPA), and the sulfhydryl borane, (BSH), seem to be ...
Jörgen, Carlsson, Erika Bohl, Kullberg, Jacek, Capala, Stefan, Sjöberg, Katarina, Edwards, Lars, Gedda   +5 more
openaire   +2 more sources

Fractionation in Boron Neutron Capture Therapy

1989
The theoretical basis has been described for the value of BNCT in the treatment of cerebral glioblastoma multiforme.1 Early clinical trials in the United States showed unexpected and excessive damage to normal brain tissue. Subsequent analysis suggests that this damage was due to high levels of boron in blood at the time of irradiation.
K R, Durrant, J, Hopewell
openaire   +2 more sources

Utilizing neutron generators in boron neutron capture therapy

Applied Radiation and Isotopes, 2021
Neutron capture therapy (NCT) is a radiotherapeutic technique that is designed to utilize the neutron capture reaction and damage the tumor cells through the energy release from the reaction. Nuclear reactors are typically utilized in this therapy because of the high neutron fluence rate that can be achieved. There has been minimal work to evaluate the
Walid A, Metwally, Yumna, Adel, Entesar Z, Dalah, Husam, Al-Omari   +3 more
openaire   +2 more sources

Boron nanodrugs for boron neutron capture therapy

Applied Radiation and Isotopes
Boron neutron capture therapy (BNCT) is a promising therapeutic method for malignant tumors, capable of selectively killing tumor cells through nuclear reactions at the single-cell level without damaging surrounding normal cells. With the rapid development of nano-delivery systems in recent years, boron nanodrugs have improved the efficiency of intra ...
Jiaxin, Wan, Linwen, Lv, Yanan, Chang, Juan, Li, Gengmei, Xing, Kui, Chen   +5 more
openaire   +2 more sources

Boron Compounds for Neutron Capture Therapy

1989
There have been two main approaches to the development of boron compounds for neutron capture therapy (BNCT). One has involved the synthesis of boronated analogues of organic structures which possess a high degree of selectivity for neoplastic cells. These include amino acids, nucleic acid precusors, porphyrins and promazines.
F, Alam, A H, Soloway, B V, Bapat, R F, Barth, D M, Adams   +4 more
openaire   +2 more sources