Results 171 to 180 of about 5,770 (216)

Ligand Liposomes and Boron Neutron Capture Therapy

Journal of Neuro-Oncology, 2003
Boron neutron capture therapy (BNCT) has been used both experimentally and clinically for the treatment of gliomas and melanomas, with varying results. However, the therapeutic effects on micro-invasive tumor cells are not clear. The two drugs that have been used clinically, p-boronophenylalanine, (BPA), and the sulfhydryl borane, (BSH), seem to be ...
Jörgen, Carlsson, Erika Bohl, Kullberg, Jacek, Capala, Stefan, Sjöberg, Katarina, Edwards, Lars, Gedda   +5 more
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Fractionation in Boron Neutron Capture Therapy

1989
The theoretical basis has been described for the value of BNCT in the treatment of cerebral glioblastoma multiforme.1 Early clinical trials in the United States showed unexpected and excessive damage to normal brain tissue. Subsequent analysis suggests that this damage was due to high levels of boron in blood at the time of irradiation.
K R, Durrant, J, Hopewell
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Boron Neutron Capture Therapy

Physics of Atomic Nuclei, 2021
Fundamentals of boron neutron capture therapy of malignant tumors are outlined, and the current status of the development of epithermal-neutron sources on the basis of charged-particle accelerators is surveyed. Attention is additionally given to a neutron source based on a charged-particle accelerator belonging to a new type—a tandem accelerator with ...
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Boron nanodrugs for boron neutron capture therapy

Applied Radiation and Isotopes
Boron neutron capture therapy (BNCT) is a promising therapeutic method for malignant tumors, capable of selectively killing tumor cells through nuclear reactions at the single-cell level without damaging surrounding normal cells. With the rapid development of nano-delivery systems in recent years, boron nanodrugs have improved the efficiency of intra ...
Jiaxin, Wan, Linwen, Lv, Yanan, Chang, Juan, Li, Gengmei, Xing, Kui, Chen   +5 more
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Boron Compounds for Neutron Capture Therapy

1989
There have been two main approaches to the development of boron compounds for neutron capture therapy (BNCT). One has involved the synthesis of boronated analogues of organic structures which possess a high degree of selectivity for neoplastic cells. These include amino acids, nucleic acid precusors, porphyrins and promazines.
F, Alam, A H, Soloway, B V, Bapat, R F, Barth, D M, Adams   +4 more
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Overview of Boron Neutron Capture Therapy in 2022

Cancer Biotherapy and Radiopharmaceuticals, 2023
In April 2022, the National Cancer Institute of the United States organized a 3-day seminar, dedicated to boron neutron capture therapy (BNCT). This short article summarizes a presentation from that event, which is intended to provide an overview of activities currently underway worldwide to make BNCT available for patient treatments.
Wolfgang A.G. Sauerwein, Miha Ulčar
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The role of boron MRI in boron neutron capture therapy

Journal of Neuro-Oncology, 1997
Boron magnetic resonance imaging (MRI) and spectroscopy (MRS) are being developed for use in boron neutron capture therapy (BNCT). With continued development, boron MRI may be used to locate BNCT agents in vivo, evaluate the pharmacokinetics of BNCT agents, and aid in treatment planning.
G W, Kabalka, C, Tang, P, Bendel
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Boronated Thymidine Analogues for Boron Neutron Capture Therapy

Nucleosides, Nucleotides and Nucleic Acids, 2006
Concise synthetic methods for synthesizing 3-carboranyl thymidine analogues (3CTAs) modified with cyclic and acyclic alcohols have been developed. The synthesis of these potential boron neutron capture therapy (BNCT) agents and their preliminary biological evaluation is described.
B T S, Thirumamagal, Jayaseharan, Johnsamuel, Guirec Y, Cosquer, Youngjoo, Byun, Junhua, Yan, Sureshbabu, Narayanasamy, Werner, Tjarks, Rolf F, Barth, Ashraf S, Al-Madhoun, Staffan, Eriksson   +9 more
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Optimization of Boron and Neutron Delivery for Neutron Capture Therapy

Pigment Cell Research, 1989
A number of groups in the United States have received funding that will permit evaluation of the clinical efficacy of the neutron capture therapy (NCT) procedure. Various reactors are being modified to allow the construction of an epithermal neutron beam.At the Brookhaven Medical Research Reactor (BMRR), the patient irradiation facility is being ...
R G, Fairchild, D N, Slatkin, J A, Coderre, P L, Micca, B H, Laster, S B, Kahl, P, Som, I, Fand, F, Wheeler   +8 more
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Boron neutron capture therapy.

The British Journal of Radiology, 1997
mal or epithermal neutron irradiation. Naturallythe Petten High Flux Reactor Centre, Holland and occurring 10B has a very high affinity for thermal at the University of Helsinki, Finland. Other neutrons, having a thermal neutron cross-section European Centres, including the UK group in of 3838 barns for the 10B(n, a) 7Li reaction.
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