Results 181 to 190 of about 5,770 (216)

Boron neutron capture therapy of a rat glioma

Neurosurgery, 1990
The purpose of the present study was to utilize a well-established rat glioma to evaluate boron neutron capture therapy for the treatment of malignant brain tumors. Boron-10 (10B) is a stable isotope which, when irradiated with thermal neutrons, produces a capture reaction yielding high linear energy transfer particles (10B + 1nth----[11B]----4He(alpha)
N R, Clendenon, R F, Barth, W A, Gordon, J H, Goodman, F, Alam, A E, Staubus, C P, Boesel, A J, Yates, M L, Moeschberger, R G, Fairchild   +9 more
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Boron neutron-capture therapy

Neutron News, 1990
Abstract Boron Neutron Capture Therapy (BNCT) is a method of radiation therapy based on the 10B(n,4He)7Li reaction that shows promise in the treatment of some malignant tumors of the brain and of the skin. Considerable research on neutron beam development and on the chemistry, pharmacology and toxicology of boron-containing drugs for BNCT is in ...
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Boron-neutron capture therapy in relation to immunotherapy

Acta Neurochirurgica, 1978
The essential feature of tumour therapy rests upon host-tumour interaction. To achieve therapeutic effects, a prerequisite to immunotherapy is the reduction of tumour cells in the host's body. Such measures should not be immunosuppressive. Cytotoxic chemotherapy is not appropriate in this regard.
H, Hatanaka, K, Amano, S, Kamano, H, Fankhauser, T, Hanamura, K, Sano   +5 more
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Reporting Dose in Boron Neutron Capture Therapy

Cancer Biotherapy and Radiopharmaceuticals, 2023
Reporting needs uniformity in definitions and terminology. This is crucial in order to be able to compare and aggregate clinical outcomes data across clinical trials. For decades, there is no standard for reporting dose in boron neutron capture therapy (BNCT).
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Boron Neutron Capture Therapy

2001
Boron neutron capture therapy in Japan was started by H. Hatanaka at HTR in 1968. Successively, four reactors (HTR, MuITR, KUR, and JRR-2) were authorized for medical use (Figure 1). He modified the method developed by W. Sweet. Furthermore, he decided to introduce BSH, which was discovered and tested by his coworker A. H.
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Carboranylporphyrins for Boron Neutron Capture Therapy of Cancer

Current Medicinal Chemistry-Anti-Cancer Agents, 2003
A major challenge for cancer treatment is the preferential and irreversible killing of tumor cells and minimal damage of normal tissues, both in the site of the malignancy and in the body. The agents used in boron neutron capture therapy (BNCT) are supposed to have the following advantages over many conventional chemotherapeutics: 1) when irradiated ...
Rima P, Evstigneeva, Andrei V, Zaitsev, Valentina N, Luzgina, Valentina A, Ol' Shevskaya, Alexander A, Shtil   +4 more
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Boron neutron capture therapy for glioblastoma multiforme

Pharmacy World & Science, 2005
Glioblastoma multiforme (GBM) is an incurable disease that can only be managed in a palliative way. The GBM accounts for approximately half of all newly diagnosed primary brain tumors with an incidence of 2-3 cases per 100,000 people each year. Surgery and radiation are the standard options for palliation, and whether there is a place for chemotherapy ...
Catharina M, van Rij, Abraham J, Wilhelm, Wolfgang A G, Sauerwein, Arie C, van Loenen   +3 more
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Phantom materials for boron neutron capture therapy

Physics in Medicine and Biology, 2000
The aim of this work was to establish which reference phantom material is most suited for dosimetry under reference conditions of neutron beams for boron neutron capture therapy (BNCT). For this purpose, phantoms of dimensions 15 x 15 x 15 cm3 and 30 x 30 x 30 cm3, composed of water, tissue-equivalent (TE) liquid, polyethylene (PE), polymethyl ...
C P J Raaijmakers, E L Nottelman, B J Mijnheer, E L Nottelman   +3 more
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Boron Neutron Capture Therapy: Principles and Potential

1998
This book on the therapeutic applications of neutrons and high-LET radiations in cancer therapy would not have been complete without a review of the present situation of boron neutron capture therapy (BNCT) and a discussion of its future perspectives.
R, Gahbauer, N, Gupta, T, Blue, J, Goodman, R, Barth, J, Grecula, A H, Soloway, W, Sauerwein, A, Wambersie   +8 more
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Liposomal Boron Delivery for Neutron Capture Therapy

2009
Tumor cell destruction in boron neutron capture therapy (BNCT) is due to the nuclear reaction between (10)B and thermal neutrons. The thermal neutrons have an energy of 0.025 eV, clearly below the threshold energy required to ionize tissue components.
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