Results 151 to 160 of about 3,740,560 (195)

Synthesis and evaluation of boron folates for Boron-Neutron-Capture-Therapy (BNCT)

Radiochimica Acta, 2015
Abstract Boron neutron capture therapy (BNCT) employs 10B-pharmaceuticals administered for the treatment of malignancies, and subsequently irradiated with thermal neutrons. So far, clinical established pharmaceuticals like boron phenylalanine (BPA) or sodium boron mercaptate (BSH) use imperfect (BPA) or passive (BSH) targeting for ...
Tobias Ross, Nicolas H Bings, Gabriele Hampel   +2 more
exaly   +2 more sources

The Finnish boron neutron capture therapy (BNCT) project

VTT Symposium, 1999
Boron neutron capture therapy (BNCT) is a new, binary radiotherapy, which is being developed especially for severe brain tumours, incurable by the present means (for an overview see articles in [1]). A suitable 10B containing carrier compound is injected into the blood circulation and taken up selectively by the cancer cells.
Auterinen, Iiro
core   +5 more sources

Translational boron neutron capture therapy (BNCT) studies for the treatment of tumors in lung

International Journal of Radiation Biology, 2019
Purpose: Boron neutron capture therapy (BNCT) combines selective accumulation of 10 B carriers in tumor tissue with subsequent neutron irradiation. BNCT has been proposed for the treatment of multiple, non-resectable, diffuse tumors in lung.
Amanda Elena Schwint, Saverio Altieri, Silva Bortolussi   +2 more
exaly   +2 more sources

Boron neutron capture therapy (BNCT): Implications of neutron beam and boron compound characteristics

Medical Physics, 1999
The potential efficacy of boron neutron capture therapy (BNCT) for malignant glioma is a significant function of epithermal‐neutron beam biophysical characteristics as well as boron compound biodistribution characteristics. Monte Carlo analyses were performed to evaluate the relative significance of these factors on theoretical tumor control using a ...
Wheeler, Floyd, Nigg, David, Capala, Jacek, Watkins, Peter, Vroegindeweij, Corine, Auterinen, Iiro, Seppälä, Tiina, Bleuel, Darren   +8 more
openaire   +2 more sources

Clinical results of boron neutron capture therapy (BNCT) for glioblastoma

Applied Radiation and Isotopes, 2011
The purpose of this study was to evaluate the clinical outcome of BSH-based intra-operative BNCT (IO-BNCT) and BSH and BPA-based non-operative BNCT (NO-BNCT). We have treated 23 glioblastoma patients with BNCT without any additional chemotherapy since 1998.
T, Kageji, Y, Mizobuchi, S, Nagahiro, Y, Nakagawa, H, Kumada   +4 more
openaire   +2 more sources

Potential of boron neutron capture therapy (BNCT) for myxofibrosarcoma

Applied Radiation and Isotopes
Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used ...
Takuya, Fujimoto, Tooru, Andoh, Tamotsu, Sudo, Ikuo, Fujita, Yoshinori, Sakurai, Takushi, Takata, Hiroki, Tanaka, Teruya, Kawamoto, Shunsuke, Yahiro, Shotaro, Nakamura, Hitomi, Hara, Naomasa, Fukase, Toshihiro, Akisue, Hideki, Ichikawa, Ryosuke, Kuroda, Minoru, Suzuki   +15 more
openaire   +2 more sources

Neutron fluence measurements for Boron Neutron Capture Therapy (BNCT)

Physicae Proceedings, 2012
The Boron Neutron Capture Therapy (BNCT) is an internal radiotherapy, in which 10 B compounds, selectively delivered to tumor cells, capture neutrons from an external source, emitting an particle and a recoil 7 Li nucleus. These two particles present high LET and their combined range (< 10 m) is in the magnitude of the cell radius, ideally affecting ...
Sandro Guedes, Bárbara Smilgys, Julio Cesar Hadler   +2 more
openaire   +1 more source

Boron neutron capture therapy (BNCT): A radiation oncology perspective

International Journal of Radiation Oncology*Biology*Physics, 1994
Boron neutron capture therapy (BNCT) offers considerable promise in the search for the ideal cancer therapy, a therapy which selectively and maximally damages malignant cells while sparing normal tissue. This bimodal treatment modality selectively concentrates a boron compound in malignant cells, and then "activates" this compound with slow neutrons ...
openaire   +2 more sources

Importance of radiobiological studies for the advancement of boron neutron capture therapy (BNCT)

Expert Reviews in Molecular Medicine, 2022
Abstract Boron neutron capture therapy (BNCT) is a tumour selective particle radiotherapy, based on the administration of boron carriers incorporated preferentially by tumour cells, followed by irradiation with a thermal or epithermal neutron beam.
openaire   +2 more sources

Potential of boron neutron capture therapy (BNCT) for epithelioid sarcoma

Applied Radiation and Isotopes
Epithelioid sarcoma (ES) is a very rare malignant tumor with few effective treatments other than surgical resection. In this study, the efficacy of BNCT for ES was examined using human ES-derived VA-ES-BJ cell-bearing nude mice. Only tumors in the BNCT group injected with p-borono-L-phenylalanine-fructose complex and irradiated with neutrons were ...
Takuya, Fujimoto, Tooru, Andoh, Tamotsu, Sudo, Toshiko, Sakuma, Ikuo, Fujita, Yoshinori, Sakurai, Takushi, Takata, Hiroki, Tanaka, Teruya, Kawamoto, Shunsuke, Yahiro, Hitomi, Hara, Naomasa, Fukase, Toshihiro, Akisue, Hideki, Ichikawa, Ryosuke, Kuroda, Minoru, Suzuki   +15 more
openaire   +2 more sources