Results 101 to 110 of about 6,117,045 (351)
Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications
Molecules, 2020 Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly due to the idea that this group could confer some toxicity. Nowadays, this concept has been demystified and, especially after the discovery of the drug bortezomib, the
Mariana Pereira Silva +3 more
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Chemoselective Suzuki-Miyaura cross-coupling via kinetic transmetallation [PDF]
, 2016 Chemoselective Suzuki-Miyaura cross-coupling generally requires a designed deactivation of one nucleophile towards transmetallation. Here we show that boronic acids can be chemoselectively reacted in the presence of ostensibly equivalently reactive ...
Fazakerley, Neal J. +2 more
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, 2014 Citation: 'boronic acids' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.B00714 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial
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Recent development of boronic acid-based fluorescent sensors
RSC Advances, 2018 As Lewis acids, boronic acids can bind with 1,2- or 1,3-diols in aqueous solution reversibly and covalently to form five or six cyclic esters, thus resulting in significant fluorescence changes.
Guiqian Fang +8 more
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Nanolayer‐Encapsulated Stretchable Liquid‐Metal Sheets for Thermal Management
Advanced Functional Materials, EarlyView.A stretchable liquid metal sheet with both high thermal conductivity and mechanical flexibility is developed. Its trilayer structure, comprising copper‐particle‐dispersed gallium liquid metal encapsulated by styrene‐butadiene‐styrene nanosheets, shows 40.4 W m−1 K−1 conductivity, elongation exceeding 200%, and retention of 96% of its initial ...
Daisuke Kuse +16 more
wiley +1 more source
Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-dimethylaminomethyl)phenyl)quinoline Derived Antitubercular Lead Compounds [PDF]
, 2016 Bedaquiline (BDQ) is a novel and highly potent last-line antituberculosis drug that was approved by the US FDA in 2013. Owing to its stereo-structural complexity, chemical synthesis and compound optimization are rather difficult and expensive. This study
Cui, HC +8 more
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Boric acid and boronic acids inhibition of pigeonpea urease [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2006 Urease from the seeds of pigeonpea was competitively inhibited by boric acid, butylboronic acid, phenylboronic acid, and 4-bromophenylboronic acid; 4-bromophenylboronic acid being the strongest inhibitor, followed by boric acid > butylboronic acid > phenylboronic acid, respectively.
K Ravi Charan, Reddy, Arvind M, Kayastha
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Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid.
Journal of the American Chemical Society, 2018 Boronic acids have been typecast as moieties for covalent complexation and are employed only rarely as agents for non-covalent recognition. By exploiting the profuse ability of a boronic acid group to form hydrogen bonds, we have developed an inhibitor ...
I. Windsor +5 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Liquid‐phase transmission electron microscopy enables direct observation of nucleation and growth processes in solution. This review is dedicated to the remembrance of Helmut Cölfen and highlights recent studies on complex materials—oxides, biominerals, organic–inorganic crystals—which were central to his research activity. It summarizes key milestones,
Charles Sidhoum +5 more
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Molecules, 2019 Histone acetylation and deacetylation play an essential role in the epigenetic regulation of gene expression. Histone deacetylases (HDAC) are a group of zinc-binding metalloenzymes that catalyze the removal of acetyl moieties from lysine residues from ...
Gnanendra Shanmugam +2 more
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