Results 121 to 130 of about 53,199 (230)

Bortezomib attenuates murine collagen-induced arthritis

, 2009
OBJECTIVES: Nuclear factor kappa B (NF-kappaB) is a major regulator of pivotal proinflammatory cytokines in the pathogenesis of rheumatoid arthritis (RA).
이수곤, 이상원, 박용범
core   +1 more source

Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean, Lara V. Graham, Christina Putnam, Rosa Gomes Alves Martins, Daniel T. Harding, Tim J. Underwood, Zoë S. Walters, Matthew D. Blunt   +7 more
wiley   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, Volume 13, Issue 49, 3 September 2026.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

The Changing Landscape of Maintenance Therapy in Newly Diagnosed Multiple Myeloma: A Systematic Review With Network Meta‐Analysis of the European Myeloma Network (EMN)

American Journal of Hematology, Volume 101, Issue 9, Page 2353-2370, September 2026.
Our meta‐analysis showed significant improvement of PFS with lenalidomide, proteasome inhibitors, and CD38‐based therapies. A significant OS benefit was noted only with lenalidomide in transplant‐eligible (TE) patients, while CD38‐directed therapy showed a trend toward improved OS.
Heinz Ludwig, Evangelos Terpos, Francesca Gay, Niels W. C. J. van de Donk, Sarah Bernhard, Monika Engelhardt, Gordon Cook, Fredrik Schjesvold, Hermann Einsele, Graham Jackson, Charlotte Pawlyn, María‐Victoria Mateos, Sonja Zweegman, Martin Schreder, Meral Beksaç, Christoph Driessen, Enrique M. Ocio, Rakesh Popat, Leo Rasche, Cyrille Touzeau, Pellegrino Musto, Annemiek Broijl, Meletios Dimopoulos, Roman Hajek, Mario Boccadoro, Pieter Sonneveld   +25 more
wiley   +1 more source

Dihydrolipoamide dehydrogenase (DLD) is a novel molecular target of bortezomib

Cell Death and Disease
Proteasome inhibitors (PIs), such as bortezomib and calfizomib, were backbone agents in the treatment of multiple myeloma (MM). In this study, we investigated bortezomib interactors in MM cells and identified dihydrolipoamide dehydrogenase (DLD) as a ...
Yu Feng, Hongmei Luo, Jingcao Huang, Yue Zhang, Jingjing Wen, Linfeng Li, Ziyue Mi, Qianwen Gao, Siyao He, Xiang Liu, Xinyu Zhai, Xin Wang, Li Zhang, Ting Niu, Yuhuan Zheng   +14 more
doaj   +1 more source

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source

A Multivariable Prediction Model for Early Mortality in Multiple Myeloma Patients With Renal Impairment

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Despite therapeutic advances, early mortality remains a significant challenge in multiple myeloma (MM) patients with renal impairment (RI), with no validated prognostic models currently available for this high‐risk subgroup. This multicenter, retrospective study aimed to develop and validate a practical nomogram for predicting early death ...
Menghan Liu, Yuan Jian, Huixing Zhou, Jing Jia, Jiachen Li, Chuanying Geng, Guangzhong Yang, Wenrong Huang, Xinan Cen, Wenming Chen, Honghu Zhu, Wen Gao   +11 more
wiley   +1 more source

Construction and Validation of a Progression‐Free Survival Prediction Model for Newly Diagnosed Multiple Myeloma Patients With 1q21 Gain/Amplification

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Objective To investigate the clinical characteristics of newly diagnosed multiple myeloma (NDMM) patients with 1q21 gain/amplification (1q21+), construct and validate a progression‐free survival (PFS) prediction model, and explore the clinical implications of model‐based risk stratification.
Yuexuan Rao, Shiyou Li, Aoyang Yu, Wenjie Yu, Zhiyuan Yao, Huanxin Zhang, Zhenyu Li   +6 more
wiley   +1 more source

Physicochemical stability of bortezomib solutions for subcutaneous administration

For the majority of cytotoxic drug preparations, such as bortezomib, the unit dose information is not available. In addition, there is a lack of information on the physicochemical stability of the pharmaceutical preparation after opening; this ...
Escobar Rodríguez, Ismael, Vicario De La Torre, Marta, Nélida Barrueco, García Díaz, Benito, Lucena Campillo, Mª Amparo, Mª Amparo Lucena-Campillo, Elena López-Lunar, Benito García-Díaz, Marta Vicario-de-la-Torre, Barrueco, Nélida, Ismael Escobar-Rodríguez, Benéitez García, Mª Cristina, María Esther Gil-Alegre, López Lunar, Elena, Ángela Gómez, Gil Alegre, María Esther, Mª Cristina Benéitez García, Gómez Alférez, Ángela   +17 more
core   +1 more source

Microproteins as a Hidden Player in Breast Cancer: From Molecular Insights to Therapeutic Potential

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Breast cancer continues to pose a public health problem and is the second leading cause of cancer‐related mortality among women globally. Despite advances in our understanding of cancer biology and the development of treatment strategies, the therapeutic response is not often satisfactory as treatment efficacy is limited by severe side effects
Qianyi Dai, Kimberly Seaman, Xin Song, Amel Sassi, Xiaolong Yang, Lidan You   +5 more
wiley   +1 more source