Results 141 to 150 of about 12,338 (219)
Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights
American Journal of Hematology, Volume 101, Issue 7, Page 1575-1588, July 2026.CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin +3 more
wiley +1 more source
TrkA abundance is increased in cutaneous nerves in bortezomib‐induced neuropathy
Brain Pathology, Volume 36, Issue 4, July 2026.Cutaneous nerves in bortezomib‐induced peripheral neuropathy (BIPN) show reduced nerve fiber density, increased TrkA expression, and enhanced dermal angiogenesis, highlighting a pathological switch in NGF/TrkA signaling that may contribute to nerve damage and pain. Abstract Tropomyosin receptor kinase A (TrkA), a high‐affinity receptor for nerve growth
Yuying Jin +14 more
wiley +1 more source
Bortezomib treatment modulates autophagy in multiple myeloma
, 2019 Although the introduction of bortezomib as a therapeutic strategy has improved the overall survival of multiple myeloma (MM) patients, 15-20% of high-risk patients do not respond to bortezomib over time or become resistant to treatment.
Saltarella Ilaria +9 more
core
Journal of Cutaneous Pathology, Volume 53, Issue 7, Page 576-580, July 2026.ABSTRACT Cutaneous crystal‐storing histiocytosis (CSH) is an extremely rare histopathologic finding of histiocytes accumulating crystals of immunoglobulin or paraproteins, often associated with lymphoplasmacytic malignancies. It commonly presents in a wide age range of both female and male adults with a history of a lymphoproliferative disorder ...
Ashton Arlen +3 more
wiley +1 more source
Journal of Clinical Periodontology, Volume 53, Issue 7, Page 990-1004, July 2026.ABSTRACT Introduction This explanatory pilot study presents a workflow to identify approved drugs, which could be repurposed for periodontitis therapy using salivary proteomics combined with drug‐target database screening. Methods Proteomic analyses of saliva using LC–MS/MS were conducted in two independent settings: a cohort (sub‐study I, N = 187) and
Taisir Bozo +11 more
wiley +1 more source
Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.Integrated physical and virtual modeling provides a scalable framework to overcome sample scarcity, recapitulate mucosal melanoma biology, and accelerate translational discovery toward precision medicine. ABSTRACT Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct ...
Xiangjie Jin +4 more
wiley +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, Volume 16, Issue 6, Page 1074-1086, June 2026.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Background Although the multiple myeloma (MM) treatment landscape has significantly advanced, MM remains an incurable disease. Accurate risk stratification and its broad clinical implementation are essential for optimizing treatment strategies. International Staging System (ISS), its revised versions (R‐ISS and R2‐ISS), and cytogenetic testing
Nami Tagami +2 more
wiley +1 more source
Synergistic Antitumor Activity of HAT Inhibitor A485 and XPO1 Inhibitor KPT8602 in Multiple Myeloma
Cancer Medicine, Volume 15, Issue 6, June 2026.ABSTRACT Background Multiple myeloma (MM) remains the second most common hematologic malignancy, necessitating the identification of novel therapeutic targets. MM is characterized by a distinct epigenetic landscape driven by aberrant chromatin activation and super‐enhancer addiction.
Hong Xu +5 more
wiley +1 more source
Cancer Reports, Volume 9, Issue 6, June 2026.ABSTRACT Introduction Systemic cervical cancer management continues to be challenging. Numerous chemotherapies have been approved, but predicting response is difficult due to the lack of biomarkers. Here, we analyze the genetic and protein profiles of 20 cervical cancer cell lines (CCCLs) and explore their correlation with drug response patterns to ...
Suzy Scholl +10 more
wiley +1 more source