Results 181 to 190 of about 12,338 (219)
The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley +1 more source
Nephrology, Volume 31, Issue 6, June 2026.ABSTRACT Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a form of monoclonal gammopathy of renal significance (MGRS) in which monoclonal immunoglobulin deposits are found within the glomerulus, without involvement of other renal compartments.
Hayley J. Duxbury +5 more
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 6, Page 3363-3380, June 2026.ABSTRACT In plants, iron homeostasis and oxygen metabolism are strictly related, indeed several Fe‐requiring enzymes catalyze reactions that also involve O2 as a reagent, product, entry or end point of the pathway. Oxygen sensing itself relies on the Fe‐dependent enzymes Plant cysteine oxidases.
Yuri Telara +9 more
wiley +1 more source
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Reactions Weekly, 2009
The ubiquitin-mediated degradation of proteins in numerous cellular processes, such as turnover and quality control of proteins, cell cycle and apoptosis, transcription and cell signaling, immune response and antigen presentation, and inflammation and development makes the ubiquitin-proteosome systems a very interesting target for various therapeutic ...
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The ubiquitin-mediated degradation of proteins in numerous cellular processes, such as turnover and quality control of proteins, cell cycle and apoptosis, transcription and cell signaling, immune response and antigen presentation, and inflammation and development makes the ubiquitin-proteosome systems a very interesting target for various therapeutic ...
+7 more sources
Hematology Meeting Reports, 2009
An increasing number of novel therapies are changing the landscape in oncology – the majority of which are novel biologicals with distinct mechanism from conventional cytotoxics. In the last decades, the discovery of the ubiquitin-proteasome pathway in eukaryotic organisms has revolutionized the understanding of cellular processes indispensable for ...
openaire +1 more source
An increasing number of novel therapies are changing the landscape in oncology – the majority of which are novel biologicals with distinct mechanism from conventional cytotoxics. In the last decades, the discovery of the ubiquitin-proteasome pathway in eukaryotic organisms has revolutionized the understanding of cellular processes indispensable for ...
openaire +1 more source