Acta Crystallographica Section E Structure Reports Online, 2012 In the title compound, C27H29N5O6S·H2O {systematic name: 4-tert-butyl-N-[6-(2-hy-droxy-eth-oxy)-5-(2-meth-oxy-phen-oxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide monohydrate], the dihedral angle between the mean planes of the pyrimidine rings is 27.0 (1)°.
Kaur, Manpreet +6 more
openaire +6 more sources
Predicting Systemic and Liver Bosentan Exposure Using Physiologically‐Based Pharmacokinetic Modeling [PDF]
CPT: Pharmacometrics & Systems PharmacologyBosentan is the first approved oral medication for pulmonary arterial hypertension, yet the black‐box warning on its labeling implies a substantial risk of liver injury associated with bosentan exposure.
Miao‐Chan Huang +6 more
doaj +2 more sources
Cardioprotective Effects of Bosentan in Rats Subjected to Lung Ischemia–Reperfusion Injury [PDF]
MedicinaObjective: This study aimed to investigate the cardioprotective effects of bosentan, an endothelin receptor antagonist, in a rat model of lung ischemia–reperfusion (I/R) injury, with a focus on myocardial tissue involvement.
Şevki Mustafa Demiröz +10 more
doaj +2 more sources
Bosentan Delivery via Nano Metal-Organic Framework nanoMIL-89 Restores Vascular Homeostasis in Pulmonary Arterial Hypertension [PDF]
International Journal of NanomedicineMashael A Al-Badr,1,2 Hanan H Abunada,1 Richa Gill,3 Hend S Fayed,4 Ayman Al Haj Zen,4 Mohammad A Al-Ghouti,3 Md Mizanur Rahman,2 Nura A Mohamed,1 Haissam Abou-Saleh5 1Biomedical Research Center, QU Health, Qatar University, Doha, Qatar; 2Biological ...
Al-Badr MA +8 more
doaj +2 more sources
Early Administration of Bosentan in High‐Risk COVID‐19 Outpatients at Risk of Sarcopenia: A Randomized, Double‐Blind, Placebo‐Controlled Trial [PDF]
Journal of Cachexia, Sarcopenia and MuscleBackground Endothelial damage induces myofibrillar breakdown and muscle degradation in COVID‐19 infection. There is a relationship between increased endothelin‐1 synthesis and sarcopenia. We evaluated the preventive effect of early bosentan therapy as an
Shaahin Shahbazi +3 more
doaj +2 more sources
Oral sildenafil versus bosentan for treatment of persistent pulmonary hypertension of the newborn: a randomized controlled trial [PDF]
BMC PediatricsBackground Access to inhaled nitric oxide (iNO) is limited in low resource settings due to non-availability and high cost. There is a need for research on low-cost alternative therapies for management of persistent pulmonary hypertension of the newborn ...
Aditya Kallimath +6 more
doaj +2 more sources
Comparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict drug induced hepatotoxicity [PDF]
, 2013 Human hepatocytes are the gold standard for toxicological studies but they have several drawbacks, like scarce availability, high inter-individual variability, a short lifetime, which limits their applicability.
Baranyai, Zsolt +4 more
core +18 more sources
American Journal of Cardiovascular Drugs, 2002 Bosentan is a nonpeptide, specific, competitive, dual antagonist at both endothelin receptor subtypes (ET(A) and ET(B)). Orally administered bosentan effectively prevents endothelin 1-induced vasoconstriction in pulmonary vessels in patients with pulmonary arterial hypertension.
Amitabh, Prakash, Caroline M, Perry
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