Results 51 to 60 of about 8,113 (209)

Impact of Bosentan in Ameliorating Methotrexate-Induced Tongue Toxicity in Rats [PDF]

المجلة العراقية للصيدلة
Background and objective: Although methotrexate has been utilized over many years, adverse effects are frequent throughout therapy, especially among cancer patients.
Rana Khairi Attarbashee
doaj   +1 more source

Using bosentan to treat paraquat poisoning-induced acute lung injury in rats. [PDF]

PLoS ONE, 2013
Paraquat poisoning is well known for causing multiple organ function failure (MODS) and high mortality. Acute lung injury and advanced pulmonary fibrosis are the most serious complications. Bosentan is a dual endothelin receptor antagonist.
Zhongchen Zhang, Xiangdong Jian, Wei Zhang, Jieru Wang, Qian Zhou   +4 more
doaj   +1 more source

Dual ETA‐ETB receptor antagonism improves metabolic syndrome‐induced heart failure with preserved ejection fraction

Fundamental &Clinical Pharmacology, Volume 39, Issue 3, June 2025.
Abstract Background Metabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET receptors are of therapeutic interest.
Francesca Lockwood, Marianne Lachaux, Najah Harouki, Matthieu Soulié, Lionel Nicol, Sylvanie Renet, Anaïs Dumesnil, Magali Vercauteren, Jeremy Bellien, Marc Iglarz, Vincent Richard, Paul Mulder   +11 more
wiley   +1 more source

The Effect of Particle Size and Surface Roughness of Spray-Dried Bosentan Microparticles on Aerodynamic Performance for Dry Powder Inhalation

Pharmaceutics, 2020
The purpose of this study was to prepare spray dried bosentan microparticles for dry powder inhaler and to characterize its physicochemical and aerodynamic properties.
Yong-Bin Kwon, Ji-Hyun Kang, Chang-Soo Han, Dong-Wook Kim, Chun-Woong Park   +4 more
doaj   +1 more source

Drug‐Related Side Effects and Contributing Risk Factors in Children With Congenital Heart Disease: A Cross‐Sectional Study

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Children with congenital heart disease (CHD) often require complex pharmacotherapy for symptom management and complication prevention. However, their unique physiological profiles increase vulnerability to drug‐related side effects.
Esmaeel Toni, Haleh Ayatollahi, Reza Abbaszadeh, Alireza Fotuhi Siahpirani   +3 more
wiley   +1 more source

Effect of Bosentan on Exercise Capacity and Clinical Worsening in Patients with Dual down and Eisenmenger Syndrome

Clinical Medicine Insights: Cardiology, 2013
This single-center, retrospective analysis evaluated long-term bosentan treatment in adult patients (n = 7) with both Down and Eisenmenger syndromes (DS-ES).
Giorgio Serino, Marco Guazzi, Angelo Micheletti, Carlo Lombardi, Rossella Danesi, Diana Negura, Mario Carminati, Massimo Chessa   +7 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Model of Tyrosine Kinase Inhibitors to Predict Target Site Penetration, with PET‐Guided Verification

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 5, Page 918-928, May 2025.
ABSTRACT Osimertinib, a tyrosine kinase inhibitor (TKI), treats non‐small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. However, its efficacy may vary due to heterogeneous drug distribution, assessable through microdosed radiolabeled drugs and positron emission tomography (PET).
Suzanne van der Gaag, Tamara Jordens, Maqsood Yaqub, Robbin Grijseels, Daan W. van Valkengoed, Evelien N. de Langen, Ruben van den Broek, Victor L. J. L. Thijssen, Adrianus J. de Langen, Mathilde C. M. Kouwenhoven, Idris Bahce, Bart A. Westerman, N. Harry Hendrikse, Imke H. Bartelink   +13 more
wiley   +1 more source

The Prognostic and Functional Impact of Multimorbidity in Systemic Sclerosis

ACR Open Rheumatology, Volume 7, Issue 4, April 2025.
Graphical Abstract *p‐value <0.05. Multimorbidity defined as Charlson Comorbidity Index scores ≥4. Abbreviations: CI (confidence interval), CKD (chronic kidney disease), COPD (chronic obstructive pulmonary disease), HAQ‐DI (health assessment questionnaire disability index), HR (hazard ratio), LVEF (left ventricular ejection fraction), IHD (ischaemic ...
Jessica L. Fairley, Dylan Hansen, Susanna Proudman, Joanne Sahhar, Gene‐Siew Ngian, Diane Apostolopoulos, Jennifer Walker, Lauren V. Host, Wendy Stevens, Mandana Nikpour, Laura Ross   +10 more
wiley   +1 more source

Two-years therapy with bosentan of pulmonary arterial hypertension related to connective tissue diseases

Reumatismo, 2011
Objective: Pulmonary arterial hypertension (PAH) is a rare but severe complication of connective tissue diseases (CTD), with a negative impact on patients survival.
M. Rizzo, S. Pontarollo, F. Tiso, R. Montisci, H. Marotta, F. Tona, S. Iliceto, F. Cozzi   +7 more
doaj   +1 more source

Importance of age at diagnosis of pulmonary hypertension in children living at high altitude: Longitudinal follow‐up of 86 patients

Pulmonary Circulation, Volume 15, Issue 2, April 2025.
Abstract Pulmonary hypertension (PH) at high altitudes presents unique characteristics due to hypobaric hypoxia. We aimed to evaluate the association between early diagnosis and clinical outcomes among children with severe PH living at high altitudes.
Gabriel F. Diaz, Carlos E. Diaz‐Castrillon, Alicia Marquez Garcia, Rachel K. Hopper, Vinicio de J. Perez   +4 more
wiley   +1 more source