Results 61 to 70 of about 15,937 (243)
Pulmonary Circulation, Volume 16, Issue 1, January 2026.ABSTRACT Pulmonary Langerhans cell histiocytosis (PLCH) frequently complicated by pulmonary hypertension (PH), which markedly worsens prognosis. We retrospectively reviewed three institutional PLCH‐PH cases treated with off‐label Sotatercept added to background triple therapy and performed a systematic review of published PLCH‐PH reports (PubMed/Embase
Giorgi Chilingarashvili +7 more
wiley +1 more source
Prognostic Factors of Renal Involvement in Systemic Sclerosis [PDF]
, 2018 Background/Aims: Renal involvement is common in systemic sclerosis (SSc), including asymptomatic reduction of glomerular filtration rate (GFR), increased renal resistance indices, scleroderma renal crisis (SRC) and ANCA-associated vasculitis. The aim was
Barbano, Biagio +5 more
core +2 more sources
Prognostic Value of Acute Vasoreactivity in Chronic Thromboembolic Pulmonary Hypertension
Pulmonary Circulation, Volume 16, Issue 1, January 2026.ABSTRACT Vasoreactivity, which refers to the reduction of mean pulmonary arterial pressure in response to inhaled vasodilators, is a well‐established metric for prognostication and treatment selection in patients with pulmonary arterial hypertension. However, the role of vasoreactivity in chronic thromboembolic pulmonary hypertension is less studied ...
Justin A. G. Uphus +10 more
wiley +1 more source
BMC Nephrology, 2020 Background Ambrisentan is a selective endothelin receptor antagonist used for the treatment of pulmonary arterial hypertension (PAH). Little is known about ambrisentan removal by hemodialysis in patients with end-stage renal disease (ESRD).
José Ramón Santos +7 more
doaj +1 more source
Darusentan, a selective endothelin A receptor antagonist, for the oral treatment of resistant hypertension [PDF]
, 2010 Resistant hypertension is defined as failure to lower blood pressure to target when a patient adheres to the maximum tolerated doses of three antihypertensive drugs including a diuretic.
Enseleit, F +2 more
core +1 more source
Respirology Case Reports, Volume 14, Issue 1, January 2026.We report the case of a patient with anti‐eIF2B‐positive SSc‐ILD managed with stepwise mycophenolate titration and subsequent nintedanib addition, accompanied by serial biomarkers and clinical follow‐up to help delineate the therapeutic course within this rare serological phenotype.
Hiro Ikeda +3 more
wiley +1 more source
Exploring BSEP Inhibition-Mediated Toxicity with a Mechanistic Model of Drug-Induced Liver Injury
Frontiers in Pharmacology, 2014 Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver.
Jeffrey L Woodhead +6 more
doaj +1 more source
Pathophysiologic correlates of exercise intolerance in adults with pulmonary hypertension and congenital heart disease [PDF]
, 2009 Imperial Users ...
Diller , Gerhard-Paul +1 more
core
Endothelin receptor antagonists for the treatment of pulmonary artery hypertension [PDF]
, 2012 AimsThe demonstration that endothelin production is upregulated in pulmonary artery hypertension (PAH) served as the rationale for developing endothelin-receptor antagonists (ERAs) as a treatment for PAH.
Komaromy, David +5 more
core +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 58-72, January 2026.Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post +4 more
wiley +1 more source