Results 41 to 50 of about 1,880 (174)

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

P53 genotype-independent anticancer effects of olibanum extract and 11-keto-beta-boswellic acid on human colorectal cancer cells

Phytomedicine Plus
Background: Colorectal cancer (CRC) is the third most common cancer, and CRC-related mortality is increasing annually. A key regulator of the cell cycle and cell death, the p53 gene, is frequently found in patients with CRC as mutants.
Yeongju Bae, Junsik Seo, Wooyoung Jeong
doaj   +1 more source

Oral Ulcerations and Phytotherapy: Potential Role of Helichrysum Essential Oil—A Literature Review

Oral Diseases, EarlyView.
ABSTRACT Background Recurrent aphthous stomatitis (RAS) is a common yet therapeutically challenging chronic inflammatory disease of the oral mucosa, characterized by recurrent, painful ulcerations that substantially affect patients' quality of life. Objective This review summarizes current evidence on phytotherapy in RAS, with particular focus on the ...
Ruzica Ivkovic, Reka Antic, Avisek Majumder, Suravi Majumder, Dragana Stanisic   +4 more
wiley   +1 more source

Juanbi Tang Attenuates Intervertebral Disc Degeneration by Suppressing p38MAPK/NF‐κB Signaling and Activating Atg5‐Dependent Autophagy to Promote Macrophage M2 Polarization: In Vivo and In Vitro Evidence

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
Graphical Abstract. Juanbi Tang (JBT) suppresses the p38MAPK/NF‐κB signaling pathway in disc‐infiltrating macrophages, simultaneously activating Atg5‐dependent autophagy. Autophagic degradation of p62/SQSTM1 consolidates NF‐κB inhibition through an autophagy–p62–NF‐κB regulatory module, facilitating macrophage M1‐to‐M2 polarization.
Ye‐Hui Wang, Wei Hou, Guo‐Sheng Tang, Xuan‐Geng Deng, Si‐Mao Song, Wei Cui, Yang Ye, Yang Yu   +7 more
wiley   +1 more source

Anti-diabetic potential of β-boswellic acid and 11-keto-β-boswellic acid: Mechanistic insights from computational and biochemical approaches

Biomedicine & Pharmacotherapy, 2022
l'acide β-boswellique (β-BA) et l'acide 11-céto-β-boswellique (β-KBA) sont des composés bioactifs cruciaux, principalement isolés de l'encens. Ces composés sont connus pour leurs puissantes activités anticancéreuses et anti-inflammatoires. Ici, nous avons exploré le potentiel antidiabétique complet du β-BA et du β-KBA avec des paramètres détaillés ...
Ajmal Khan, Imran Khan, Sobia Ahsan Halim, Najeeb Ur Rehman, Nasiara Karim, Waqar Ahmad, Majid Khan, René Csük, Reaz Uddin   +8 more
openaire   +4 more sources

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, Volume 40, Issue 8, Page 4759-4791, August 2026.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Frankincense and myrrh and their bioactive compounds ameliorate the multiple myeloma through regulation of metabolome profiling and JAK/STAT signaling pathway based on U266 cells

BMC Complementary Medicine and Therapies, 2020
Background Frankincense and myrrh are used as traditional anti-inflammatory and analgesic medicines in China. It has been reported that frankincense and myrrh have significant anti-tumor activities.
Rumeng Gao, Xiaodong Miao, Chengjing Sun, Shulan Su, Yue Zhu, Dawei Qian, Zhen Ouyang, Jinao Duan   +7 more
doaj   +1 more source

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens

BMC Research Notes, 2011
Background Boswellic acids mixture of triterpenic acids obtained from the oleo gum resin of Boswellia serrata and known for its effectiveness in the treatment of chronic inflammatory disease including peritumor edema.
Shawl Abdul S, Khan Inshad A, Ali Furqan, Raja Alsaba F, Arora Daljit S   +4 more
doaj   +1 more source

Urease inhibitory activities of β-boswellic acid derivatives [PDF]

DARU Journal of Pharmaceutical Sciences, 2013
Abstract Background and the purpose of the study Boswellia carterii have been used in traditional medicine for many years for management different gastrointestinal disorders. In this study, we wish to report urease inhibitory activity of four isolated compound of boswellic acid derivative.
Golbabaei, Sanaz, Bazl, Roya, Golestanian, Sahand, Nabati, Farzaneh, Omrany, Zinat Bahrampour, Yousefi, Behnam, Hajiaghaee, Reza, Rezazadeh, Shamsali, Amanlou, Massoud   +8 more
openaire   +2 more sources