Results 1 to 10 of about 3,264 (197)

Sublingual AKBA Exerts Antidepressant Effects in the Aβ-Treated Mouse Model [PDF]

Biomolecules, 2021
The 3-O-acetyl-11-keto-β-boswellic acid (AKBA) is the most active compound of Boswellia serrata proposed for treating neurodegenerative disorders, including Alzheimer’s disease (AD), characterized in its early phase by alteration in mood. Accordingly, we
Maria Grazia Morgese, Matteo Francavilla, Stefania Schiavone   +2 more
exaly   +6 more sources

Unphosphorylated STAT1 binds to the BST2 transcription promoter, promoting increased AKBA anchoring on HPMECs to alleviate ARDS [PDF]

Scientific Reports
Although the drug therapeutic targets of acute respiratory distress syndrome (ARDS) are still unclear and no specific drugs for ARDS treatment have been found, some breakthroughs have been gradually made in the biological target pathways such as ...
Kaili Li, Zixiang Zhou, Feng Liu, Zuotian Huang, Xiaoying Chen, Fachun Zhou   +5 more
doaj   +4 more sources

Antimicrobial topical polymeric films loaded with Acetyl-11-keto-β-boswellic acid (AKBA), boswellic acid and silver nanoparticles: Optimization, characterization, and biological activity [PDF]

Heliyon
The study examined the antimicrobial and antioxidant potential of pure Acetyl-11-keto-β-boswellic acid (AKBA), boswellic acid (70%) and AKBA loaded nanoparticles as topical polymeric films. The optimized concentration (0.05 % w/v) of pure AKBA, boswellic
ESRA KOCA, Sevgin Diblan
exaly   +4 more sources

Surface-engineered hyaluronic acid-coated lyotropic liquid crystalline nanoparticles for CD44-targeting of 3-Acetyl-11-keto-β-boswellic acid in rheumatoid arthritis treatment [PDF]

Journal of Nanobiotechnology
Background In the current era of the global increase in autoimmune and inflammatory disorders, predominantly rheumatoid arthritis (RA), there is mounting interest in developing advanced, safe, and patient-compliant treatment strategies. Phytoconstituents
Sakshi Priya, Vagesh Verma, Aniruddha Roy, Gautam Singhvi   +3 more
doaj   +2 more sources

Acetyl-11-keto-β-boswellic acid alleviates hepatic metabolic dysfunction by inhibiting MGLL activity [PDF]

Journal of Lipid Research
Metabolic abnormalities have emerged as a central pathogenesis in various metabolic diseases, particularly nonalcoholic fatty liver disease (NAFLD) and its associated complications of obesity and insulin resistance. Despite this, effective pharmaceutical
Kai Luan, Yuhong Fan, Qin Yang, Hailong Yang, Zelin Zhou, Ju Huang, Zhigang She, Toujun Zou, Hui Xiong, Zhinan Mei   +9 more
doaj   +2 more sources

Synergistic Induction of Apoptosis by Boswellic Acid and Cisplatin in A549 Lung Cancer Cells Through NF-κB Modulation and p53 Pathway Activation [PDF]

Current Issues in Molecular Biology
The increasing resistance to chemotherapeutic agents in lung cancer significantly contributes to its high mortality. Natural compounds such as acetyl-11-keto-β-boswellic acid (AKBA) have emerged as promising adjuncts to standard therapies.
Mehmet Uğur Karabat, Mehmet Cudi Tuncer
doaj   +2 more sources

Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway [PDF]

Acta Biochimica et Biophysica Sinica
Synovial inflammation plays a key role in osteoarthritis (OA) pathogenesis. Fibroblast-like synoviocytes (FLSs) represent a distinct cell subpopulation within the synovium, and their unique phenotypic alterations are considered significant contributors ...
Zhou Jing, Li Xueyan, Han Zeyu, Qian Yinhua, Bai Lang, Han Qibin, Gao Maofeng, Xue Yi, Geng Dechun, Yang Xing, Hao Yuefeng   +10 more
doaj   +2 more sources

Development of a nanoemulsion incorporating 3-acetyl-11-keto-β-boswellic acid (AKBA): solubility and oral bioavailability through in vitro and in vivo studies [PDF]

BMC Biotechnology
Background 3-Acetyl-11-keto-β-boswellic acid (AKBA) has attracted considerable interest due to its therapeutic potential against inflammatory and cancer-related disorders.
Najmeh Ketabchi, Seyed Nasser Ostad, Mahmoud Ghazi-Khansari, Hossein Ghanbari, Fariba Esmaeili, Amir Amani   +5 more
doaj   +2 more sources

Acetyl-11-keto-β-boswellic acid attenuates tau oligomer-induced neurotoxicity in neuroblastoma cell model [PDF]

BMC Neuroscience
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by microtubule destabilization, neuroinflammation, and tau pathology.
Shahnaz Pourhossein, Ibrahim Bahrami Mianrood, Seyyed Hossein Khatami, Sajad Ehtiati, Majid Ghasemian, Farzad Mokhtari, Reyhane Ahmadzade, Marziyeh Goudarzi, Nastaran Hamed, Fatemeh Namvarjah, Saeed Karima   +10 more
doaj   +2 more sources

Effects of 1H-1,2,3-Triazole Derivatives of 3-O-Acetyl-11-Keto-Beta-Boswellic Acid from Boswellia sacra Resin on T-Cell Proliferation and Activation [PDF]

Pharmaceuticals
Background: 3-O-acetyl-11-keto-β-boswellic acid (β-AKBA), a triterpene natural product, is one of the main natural products of Boswellia sacra resin (BSR) and has reported biological and immunomodulatory effects.
Abdo Meyiah, Satya Kumar Avula, Ahmed Al-Harrasi, Eyad Elkord   +3 more
doaj   +2 more sources