Results 51 to 60 of about 15,057,084 (238)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Cost of photochemical machining [PDF]

, 2004
Photochemical machining (PCM), also known as photoetching, photofabrication or photochemical milling, is a non-traditional manufacturing method based on the combination of photoresist imaging and chemical etching.
Roy, Rajkumar, Allen, David M., Zamora, Oscar   +2 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Numerical evaluation of cutting strategies for thin-walled parts

Scientific Reports
Static form errors due to in-process deflections is a major concern in flank milling of thin-walled parts. To increase both productivity and part geometric accuracy, there is a need to predict and control these form errors.
Andreas Andersson Lassila, Daniel Svensson, Wei Wang, Tobias Andersson   +3 more
doaj   +1 more source

Anisotropic mechanism of material removal and ductile-brittle transition in sapphire scratching based on acoustic emission signal

Journal of Materials Research and Technology
Sapphire exhibits typical anisotropy due to its unique crystal structure, and there are significant property differences in different processing areas during the machining of curved sapphire component, making it essential to investigate the anisotropy in
Xingyu Wang, Yongchen Ning, Wen Zheng, Xiaoyu Bao, Qingliang Zhao, Sheng Wang   +5 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A simulated investigation on the machining instability and dynamic surface generation [PDF]

, 2005
In this paper, the authors propose the generic concept of machining instability based on the analysis of all kinds of machining instable behaviors and their features.
Luo, X K, Cheng, K, Luo, X
core   +1 more source

Targeted Microforming of Borosilicate Glass Induced by a Laser‐Ablation‐Free Process Using Femtosecond Pulses

Advanced Materials Interfaces
The use of ultrashort pulse lasers opens up a wide range of possibilities for processing dielectric materials. The present study focuses on the investigation of the ablation‐free microscopic surface modification of borosilicate glass using femtosecond ...
Marina Skiba, Steffen Resche, Michael Seiler, Andrés Fabián Lasagni, Jens Bliedtner   +4 more
doaj   +1 more source

Dynamic response mechanism of layered coatings under impacts: Insights from the perspective of stress wave

Materials & Design
Precision machining operations often lead to the failure of protective coatings on cutting tools due to common issues such as cracking, delamination, and peeling from cyclic impacts.
Mai Yang, Rong Tu, Mingquan Jiang, Wei Liu, Tenghua Gao, Baifeng Ji, Jun Li, Song Zhang, Lianmeng Zhang   +8 more
doaj   +1 more source