Results 41 to 50 of about 4,214 (209)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Numerical evaluation of cutting strategies for thin-walled parts

Scientific Reports
Static form errors due to in-process deflections is a major concern in flank milling of thin-walled parts. To increase both productivity and part geometric accuracy, there is a need to predict and control these form errors.
Andreas Andersson Lassila, Daniel Svensson, Wei Wang, Tobias Andersson   +3 more
doaj   +1 more source

Anisotropic mechanism of material removal and ductile-brittle transition in sapphire scratching based on acoustic emission signal

Journal of Materials Research and Technology
Sapphire exhibits typical anisotropy due to its unique crystal structure, and there are significant property differences in different processing areas during the machining of curved sapphire component, making it essential to investigate the anisotropy in
Xingyu Wang, Yongchen Ning, Wen Zheng, Xiaoyu Bao, Qingliang Zhao, Sheng Wang   +5 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Targeted Microforming of Borosilicate Glass Induced by a Laser‐Ablation‐Free Process Using Femtosecond Pulses

Advanced Materials Interfaces
The use of ultrashort pulse lasers opens up a wide range of possibilities for processing dielectric materials. The present study focuses on the investigation of the ablation‐free microscopic surface modification of borosilicate glass using femtosecond ...
Marina Skiba, Steffen Resche, Michael Seiler, Andrés Fabián Lasagni, Jens Bliedtner   +4 more
doaj   +1 more source

Dynamic response mechanism of layered coatings under impacts: Insights from the perspective of stress wave

Materials & Design
Precision machining operations often lead to the failure of protective coatings on cutting tools due to common issues such as cracking, delamination, and peeling from cyclic impacts.
Mai Yang, Rong Tu, Mingquan Jiang, Wei Liu, Tenghua Gao, Baifeng Ji, Jun Li, Song Zhang, Lianmeng Zhang   +8 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

RESEARCH OF HYDRAULIC IMPACT ON THE TECHNOLOGICAL STABILITY OF SHALLOW METROTUNNEL IN DREDGING MASSIVES

Nauka ta progres transportu, 2017
Purpose. On the basis of the results analysis of the computer simulation and laboratory studies it is necessary to determine the changes impact dependence of the hydraulic level of groundwater on the tunnels processing stability in the underground due to
S. M. Stovpnyk, A. L. Han, E. A. Zahoruiko, L. V. Shaidetska   +3 more
doaj   +1 more source