Results 31 to 40 of about 15,057,084 (238)

Statistical Analysis of Burr Width and Height in Conventional Speed Micro-Milling of Titanium Alloy (Ti-6Al-4V) by Varying Cutting Parameters Under Different Lubrication Methods: Dry, MQL and Wet

Engineering Proceedings
In this research, micro-milling of Ti-6Al-4V has been carried out in the conventional machining range. The influence of key machining parameters, including feed rate, cutting speed, depth of cut, and cooling conditions, was statistically analyzed in ...
Gulfam Ul Rehman, Muhammad Rizwan ul Haq, Manzar Masud, Syed Husain Imran Jaffery, Muhammad Salman Khan, Shahid Ikramullah Butt   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Mathematical Modeling and Generating Method of Hourglass Worm Gear Hob’s Rake Face Based on a Rotating Paraboloid Surface

Machines
The rake angles on both sides of the cutting edges of the hourglass worm gear hob significantly influence its cutting performance, which, in turn, plays a decisive role in the surface quality of the machined worm wheel.
Yupeng Li, Jie Yang, Run Gu, Zhijiang Chen, Chunming Xia   +4 more
doaj   +1 more source

Study on Influence of Asymmetric Air Gap on Damping Performanceof Eddy Current Retarder

Yuanzineng kexue jishu, 2023
The double-sided permanent magnet eddy current retarder, equipped with a set of magnets at a certain air gap on both sides of the conductor disk to make it rotate in the alternating magnetic field to generate the damping torque, has important ...
WU Hongyu;YAN He;DONG Yujie;DIAO Xingzhong
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

In-plane compressive responses and failure behaviors of composite sandwich plates with resin reinforced foam core

Heliyon
The paper presented an experimental study on the effect of the resin reinforced core configuration and core thickness on in-plane compressive responses and failure behaviors of composite sandwich specimens.
Zhiwen Qin, Xiaofei Song, Caicai Liao, Lu Yu, Xin Liu, Shu Yan, Xinkai Li   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effect of diffusion of elements on microstructural, mechanical, and machining characteristics of Al7075/ZnAl4 functionally graded material with and without Ag and Pb interface

Journal of Alloys and Metallurgical Systems
The current experimental work uses die casting, a liquid processing method, to create functionally graded material (FGM). To reduce the production of undesired intermetallic compounds, the FGM samples were created both with and without interfacing foil ...
T. Raviteja, B. Surekha, Priyaranjan Samal, Nitin Sharma   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

See Both Sides: A practical guide to gender analysis for quality service delivery [PDF]

, 2004
Published by Oxfam GB's UK Poverty Programme Gender analysis has been used in international development for many years. It is now widely recognised that a better understanding of the particular needs of women and men makes a significant difference in the
Richardson, Karen
core   +1 more source