Results 1 to 10 of about 11,918 (210)

Antimicrobial peptidomes of Bothrops atrox and Bothrops jararacussu snake venoms [PDF]

Amino Acids, 2021
The worrisome emergence of pathogens resistant to conventional drugs has stimulated the search for new classes of antimicrobial and antiparasitic agents from natural sources. Antimicrobial peptides (AMPs), acting through mechanisms that do not rely on the interaction with a specific receptor, provide new possibilities for the development of drugs ...
Saulo Luis da Silva, Cleopatra Alves Da Silva Caldeira, Daniel C Pimenta   +2 more
exaly   +5 more sources

Systemic impact of intramuscular snake envenomation and intravenous immunoglobulin-based antivenom treatment on murine plasma proteome and peptidome. [PDF]

Protein Sci
Abstract Snake envenomation remains a critical global public health challenge. In Brazil, the genus Bothrops is responsible for most accidents, typically resulting in coagulopathy, hemorrhage, and renal failure. Despite its clinical prevalence, the molecular mechanisms driving plasma protein disturbances remain poorly understood.
de Barros BCSC, Chaves AFA, Morone MSLC, Sachetto ATA, Santoro ML, Schilling O, Serrano SMT.   +6 more
europepmc   +2 more sources

Bothrops venom variation drives niche-specific pharmacology through Ca2+ signalling and membrane damage [PDF]

Frontiers in Pharmacology
Snake venom activity exhibits evolutionary patterns within genera and varies according to ecological niche. By examining venoms from species inhabiting distinct environments, niche-specific functional differences can be uncovered. Bothrops, a diverse and
Lachlan A. Bourke, Lachlan A. Bourke, Julien Slagboom, Julien Slagboom, Matthew A. Waller, G. Gregory Neely, Jeroen Kool, Jeroen Kool, Fernanda C. Cardoso, Fernanda C. Cardoso, Fernanda C. Cardoso   +10 more
doaj   +2 more sources

Comparative Hemostatic Effects of Bothrops spp. and Daboia russelii Venoms [PDF]

Biochemistry Research International
Venoms from Bothrops species and Daboia russelii are among the leading causes of venom-induced coagulopathy and snakebite-related deaths. In this study, we comparatively evaluated the biochemical composition and hemostatic effects of venoms from seven ...
Geovanna M. Malchias-Pires, Marcela Romanazzi, José R. Almeida, Jarred Williams, Pradeep Vijayakumar, Soheil Gilabadi, Rui Seabra Ferreira Júnior, Sakthivel Vaiyapuri, Manuela Berto Pucca   +8 more
doaj   +2 more sources

Snakebites by Bothrops taeniatus: characteristics of snakebites involving a rare venomous snake in Brazil [PDF]

Einstein (São Paulo)
Snakebites from the genus Bothrops account for up to 90% of venomous snakebites in Brazil. Among these species, Bothrops taeniatus is considered rare in Brazil, with only one reported case in the literature.
Paula Cristina Yukari Suzaki Fujii, Bruna Seffrin Soares, Eduarda Scoto Dias, Henrique Lira Borges, Daniel Emilio Dalledone Siqueira, Ramon Cavalcanti Ceschim   +5 more
doaj   +2 more sources

Rapid, label-free surface plasmon resonance discrimination between Bothrops and Crotalus venoms using clinical antivenom as the capture reagent. [PDF]

PLoS Neglected Tropical Diseases
Snake envenoming is recognized as a global health problem, affecting thousands of people every year. One of the main challenges in addressing this issue is the correct identification and treatment of these envenomations, particularly in locations where ...
Ely S F Borges, Jomar S Vasconcelos, Arthur A Melo, Fernanda C C L Loureiro, Karla P O Luna, Antonio M N Lima   +5 more
doaj   +2 more sources

Experimental Bothrops atrox envenomation: Efficacy of antivenom therapy and the combination of Bothrops antivenom with dexamethasone. [PDF]

PLoS Neglected Tropical Diseases, 2017
Bothrops atrox snakes are the leading cause of snake bites in Northern Brazil. The venom of this snake is not included in the antigen pool used to obtain the Bothrops antivenom. There are discrepancies in reports on the effectiveness of this antivenom to
Gabriella Neves Leal Santos Barreto, Sâmella Silva de Oliveira, Isabelle Valle Dos Anjos, Hipocrates de Menezes Chalkidis, Rosa Helena Veras Mourão, Ana Maria Moura-da-Silva, Ida Sigueko Sano-Martins, Luis Roberto de Camargo Gonçalves   +7 more
doaj   +4 more sources

Factors Associated with Systemic Bleeding in Bothrops Envenomation in a Tertiary Hospital in the Brazilian Amazon

Toxins, 2019
Bothrops snakebites usually present systemic bleeding, and the clinical–epidemiological and laboratorial factors associated with the development of this manifestation are not well established.
Jacqueline De Almeida Gonçalves Sachett, Vanderson Sampaio, Wuelton Monteiro   +2 more
exaly   +3 more sources

Complete Mitochondrial Genome of <i>Ovophis makazayazaya</i> (Viperidae, Crotalinae) and Phylogenetic Analysis. [PDF]

Ecol Evol
This study sequenced and annotated the complete 17,230 bp mitochondrial genome of Ovophis makazayazaya, which contains 13 protein‐coding genes (PCGs), 2 rRNAs, 22 tRNAs, and a D‐loop region, with a significant AT bias (57.2%). Phylogenetic analyses confirmed its placement within Crotalinae, and all PCGs showed evidence of purifying selection (Ka/Ks < 1)
Jiang Y, Nie Y, Ge Z.
europepmc   +2 more sources

Renal Effects and Nitric Oxide Response Induced by Bothrops atrox Snake Venom in an Isolated Perfused Kidney Model [PDF]

Toxins
The snakes from the genus Bothrops are responsible for most of the ophidic accidents in Brazil, and Bothrops atrox represents one of these species. Envenomation by these snakes results in systemic effects and is often associated with early mortality ...
Terentia Batista Sa Norões, Antonio Rafael Coelho Jorge, Helena Serra Azul Monteiro, Ricardo Parente Garcia Vieira, Breno De Sá Barreto Macêdo   +4 more
doaj   +2 more sources