Results 21 to 30 of about 6,759 (190)

A New Platelet-Aggregation-Inhibiting Factor Isolated from Bothrops moojeni Snake Venom. [PDF]

Biomed Res Int, 2017
This work reports the purification and functional characterization of BmooPAi, a platelet‐aggregation‐inhibiting factor from Bothrops moojeni snake venom. The toxin was purified by a combination of three chromatographic steps (ion‐exchange on DEAE‐Sephacel, molecular exclusion on Sephadex G‐75, and affinity chromatography on HiTrap™ Heparin HP ...
de Sousa BB, Mamede CCN, Matias MS, Pereira DFDC, de Queiroz MR, Dias EHV, Silva ACA, Dantas NO, Costa JO, de Oliveira F.   +9 more
europepmc   +2 more sources

Comparative Hemostatic Effects of <i>Bothrops</i> spp. and <i>Daboia russelii</i> Venoms. [PDF]

Biochem Res Int
Venoms from Bothrops species and Daboia russelii are among the leading causes of venom‐induced coagulopathy and snakebite‐related deaths. In this study, we comparatively evaluated the biochemical composition and hemostatic effects of venoms from seven Bothrops species and D. russelii using protein profiling and functional coagulation assays.
Malchias-Pires GM, Romanazzi M, Almeida JR, Williams J, Vijayakumar P, Gilabadi S, Ferreira Júnior RS, Vaiyapuri S, Pucca MB.   +8 more
europepmc   +2 more sources

Treatment with a Zinc Metalloprotease Purified from Bothrops moojeni Snake Venom (BmooMP-Alpha-I) Reduces the Inflammation in an Experimental Model of Dextran Sulfate Sodium-Induced Colitis. [PDF]

Mediators Inflamm, 2019
It has been described that the metalloprotease BmooMP‐alpha‐I purified from Bothrops moojeni snake venom is able to hydrolyze the TNF molecule. However, this observation has been based mainly on in vitro investigation, in addition to molecular modeling and docking approaches.
Silva MC, Sales-Campos H, Oliveira CJF, Silva TL, França FBF, Oliveira F, Mineo TWP, Mineo JR.   +7 more
europepmc   +2 more sources

Efeitos do soro antibotrópico nas alterações hemodinâmicas induzidas em cães pelo veneno de Bothrops moojeni Effect bothropic antivenom on haemodynamics changes induced in dog by the Bothrops moojeni poison

Acta Cirúrgica Brasileira, 2000
Para determinar o efeito do soro antibotrópico nas alterações hemodinâmicas utilizou-se 16 cães machos mestiços, sedados e mantidos intubados sob respiração espontânea.
Edivar Pereira dos Santos, Elmiro Santos Resende, Paulo Vítor Portella da Silveira, Djalma José Fagundes   +3 more
doaj   +2 more sources

Drug Discovery for Snakebite Envenoming: Wanderings Amid Historical Antidotes and Emerging Therapeutic Opportunities. [PDF]

ChemMedChem
In this review, we provide an overview of selected historical antidotes against snakebite envenomation used in early modern Europe. Then, the evidence‐based antivenom activity of some natural compounds is discussed as resulting from more than two decades of research studies.
Bianconi E, Camaioni E, Oszajca P, Macchiarulo A.   +3 more
europepmc   +2 more sources

Acidente botrópico (Bothrops moojeni) com ferimento ocular

, 1993
A 5-year-old girl was bitten in her left eye by a lance-headed viper identified as Bothrops moojeni, measuring 115 cm of length. There was severe facial swelling and left exophthalmus, and enucleation of the eye was necessary. The patient apparently had mild systemic envenoming, but local inflammatory signs and histological evidence of necrosis suggest
Brandão, Érico Otaviano, Bastos, Helder Castro de, Nishioka, Sérgio de Andrade, Silveira, Paulo Vitor Portella   +3 more
openaire   +2 more sources

Effects on cell cycle progression and cytoskeleton organization of five Bothrops spp. venoms in cell culture-based assays

Heliyon, 2023
Snake envenomation is a neglected tropical disease. In Brazil, the Bothrops genus is responsible for about 86% of snakebite accidents. Despite extensive evidence of the cytotoxicity of snake venoms, the cellular and molecular mechanisms involved are not ...
Bianca Sayuri Takayasu, Sheila Silva Rodrigues, Carlos Eduardo Madureira Trufen, Glaucia Maria Machado-Santelli, Janice Onuki   +4 more
doaj   +1 more source

Identification and characterization of Bothrops moojeni venom with MALDI TOF/RTOF mass spectrometry

, 2008
Die Zusammensetzung des Schlangengiftes vom Bothrops moojeni was mit Hilfe von preparativen und analytischen Separationstechniken untersucht. Schliesslich, die Proteine waren mit MALDI TOF mass spectrometry identifieziert.The composition of Bothrops ...
Çandarlioǧlu, Lütfiye Pelin
core   +4 more sources

Genetic variability, management, and conservation implications of the critically endangered Brazilian pitviper Bothrops insularis

Ecology and Evolution, Volume 10, Issue 23, Page 12870-12882, December 2020., 2020
This is the first report focusing on the conservation genetics of Bothrops insularis, an endemic critically endangered Brazilian snake. We recovered low (allelic content) and medium (heterozygosity) genetic diversity indexes, significant inbreeding coefficient for the in situ population and a slight genetic structure within and between populations ...
Igor Salles‐Oliveira, Taís Machado, Karina Rodrigues da Silva Banci, Selma M. Almeida‐Santos, Maria José de J. Silva   +4 more
wiley   +1 more source

Genetic relationships among species of the genus Bothrops based on RAPD markers

Brazilian Archives of Biology and Technology, 2005
The genetic relationships among 11 species of Bothrops found in Brazil were determined using random amplified fragment (RAPD) information. A total of 239 amplified bands were scored using 20 aleatory primers.
Felipe Grazziotin, Sergio Echeverrigaray
doaj   +1 more source