Results 101 to 110 of about 458,745 (304)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Modelling of the Present Oceanographic Situation of the Gulfs of Patras and Corinth

Journal of Marine Science and Engineering
In our study we investigated the hydrodynamic circulation of the Gulfs of Patras and Corinth through modelling. To this end, ROMS was used to numerically calculate the parameters of the waters for these peculiar semi-enclosed basins.
Basile Caterina, Aurélia Hubert-Ferrari, Alexander Barth, Jean-Marie Beckers   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hunting for exotic doubly hidden-charm/bottom tetraquark states

, 2017
We develop a moment QCD sum rule method augmented by fundamental inequalities to study the existence of exotic doubly hidden-charm/bottom tetraquark states made of four heavy quarks.
Chen, Hua-Xing, Chen, Wei, Liu, Xiang, Steele, T. G., Zhu, Shi-Lin   +4 more
core   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Trawling-Induced Sedimentary Dynamics in Submarine Canyons of the Gulf of Palermo (SW Mediterranean Sea)

Journal of Marine Science and Engineering
Bottom trawling in submarine canyons can affect their sedimentary dynamics, but studies addressing this topic are still scarce. In the Gulf of Palermo (NW Sicily, SW Mediterranean Sea), bottom trawling occurs on the continental slope, but principally ...
Marta Arjona-Camas, Claudio Lo Iacono, Pere Puig, Tommaso Russo, Albert Palanques   +4 more
doaj   +1 more source

Report and preliminary results of RV METEOR Cruise M78/3. Sediment transport off Uruguay and Argentina: from the shelf to the deep sea ; 19.05.2009 – 06.07.2009, Montevideo (Uruguay) – Montevideo (Uruguay) [PDF]

, 2012
The waters off Uruguay and Northern Argentina offer the possibility to study sediment transport processes from ‘source-to-sink’ in a relatively small area.
Krastel, Sebastian, Wefer, Gerold
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Acoustic tracking of woodhead seabed drifters [PDF]

An investigation was conducted to determine the feasibility of tracking Woodhead seabed drifters that were instrumented with miniature acoustic transmitters having a range in water in excess of 1.0 n.mi.
Lovelady, R. W., Mayhue, R. J.
core   +1 more source

RRS Discovery Cruise D359, 17 Dec 2010-14 Jan 2011. RAPID moorings cruise report [PDF]

, 2011
This cruise report covers scientific operations conducted during RRS Discovery Cruise D359. Cruise D359 departed from São Antonio, Cape Verde on Friday 17th December 2010 arriving Santa Cruz de Tenerife Friday 14th December 2011.The purpose of the cruise
Cunningham, S.A., et al,
core